The Effect Of Different Cardiac Functional Grading On Renal Function

Objective:Tostudyonthe relationship between serum B-type natriuretic peptide(BNP)and renal function,further investigate the effect of different cardiac functional grading on renal function,for the purpose to accumulate clinical data of early prevention of renal injury in patients with cardiovascular disease(CVD).Methods:Randomly selected patientswith cardiac insufficiency in Department of Cardiology during May 2016 to December 2016 in the Affiliated Hospital of Qinghai University,who were collected gender,age,primary disease,biochemical indicator andurine indicator.According to the revised NYHA classification of the American Heart Association,the patients were divided into 3 groups: group ?????.Usingautomatic biochemical analyzer,automatic urine analyzer and fluorescence immunoassay analyzer to measure the serum blood urea nitrogen(BUN),serumcreatinine(Scr),cystatin-c(Cys-C),urine pH,urine specific gravity(USG),BNP levels.The MDRD formula was used to calculate eGFR.Objective to observe and compare the relationship between the patients withdifferent cardiac functional grading and the general data,the incidence of the disease and the related clinical indexes,and to carry out the Spearman correlation analysis.Using SPSS 22.0 software to process data,P< 0.05 was statistically significant.Results: 1.Total108 patients with 61 males(56.48%)and 47 females(43.52%),inwhichtheaverage age of male and femalewas64.87�11.25yearsoldand65.96 �11.77 yearsold,wereselectedintotheresearch.The composition of primary disease in patients with different cardiac functional grading was difference,which was statistically significant(P < 0.05).In particular,group ?of a total of 36 patients,mainly including 13 patients(36.11%)with coronary heart disease and 8 patients(22.22%)with complications.In group of a total of 40 patients,mainly there were ?15patients(37.50%)with complications,8 patients(20.00%)with dilated cardiomyopathy,and 7 patients(17.50%)with chronic pulmonary heart disease.In group ? of a total of 32 patients,mainly there were 19 patients(37.50%)with complications and 7 patients(21.88%)with dilated cardiomyopathy.2.In CVD patients with different cardiac functional grading,theserum BNP?BUN?Cys-C?eGFR and dipstick proteinuria wereboth statistically significant(P<0.05).Butno significantlydifferentwas found between group and group in the level of ? ? Scr(P>0.05).3.The level of BNP in serum of patients with CVD was positively correlated with BUN?Cys-C and dipstick proteinuria(r=0.586,P< 0.05;r=0.429,P < 0.05;r=0.393,P < 0.05).Conclusion: 1.In patients with different cardiac functional grading,the worse the cardiac function,the higher the qualitative level of serum BNP,BUN,Scr,Cys-C,dipstick proteinuria,and lower the level of eGFR.2.The levels of serum BUN?Cys-C and dipstick proteinuria were correlated with the level of serum BNP in patients with CHF.The level of serum BNP can reflect renal function.3.For CHF patients,the worse the heart function,the greater the effect on renal function.4.Theserum Cys-C levels may reflect increased severity of heart failure.