| Objective: To investigate the effects of atorvastain and different doses of rosuvastain on the levels of lipoprotein-associated phospholipase A2(Lp-PLA2)and high-sensitivity C-reactive protein(Hs-CRP)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).To observe the relationship between the level of Lp-PLA2,Hs-CRP and the severity of coronary artery.Methods:1 A total of 90 patients with ACS who undergoing PCI were enrolled from January 2016 to October 2016 in the Fifth Department of Cardiology of Cangzhou Central Hospital.The patients were randomly divided into three groups: 1)routine dose group of rosuvastain(10mg rosuvastain every night;n=29);2)routine dose group of atorvastatin(20mg atorvastatin every night;n=31);3)intensive dose group of rosuvastain(10mg rosuvastain every night,20 mg every night from the day preoperative to three days after PCI,then10 mg every night;n=30).The demographics of all patients were recorded and analysed,including age,gender,body mass index(BMI),systolic blood pressure(SBP),heart rate(HR),smoking history,hypertension history,diabetes history,glucose,total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),final diagnosis.2 The coronary artery lesions(the number of lesions,location and degree of stenosis)were observed according to the results of coronary angiography.The severity of coronary artery lesions were evaluated by Gensini score.Then the relationship between the level of Lp-PLA2,Hs-CRP and the severity of coronary artery lesion were analysed.3 The Lp-PLA2,Hs-CRP and other indexes of patients were measured at the day before PCI,24 hours,and 72 hours after PCI.We compared the differences of these indexes among three groups.4 All data were analysed with SPSS 19.0 software.For normally distributed values,continuous variables were performed as mean value ±standard deviation,multiple sets of data comparison used single factor analysis of variance,data comparison between groups were compared by LSD-t test when P values ? 0.05.Data were expressed as median(interquartile range)and compared by Kruskal-Wallis H test among groups which did not obey normal distribution.Count data were summarized as percentage and compared by the use of chi-square test among groups.For correlation analysis,Spearman correlation analysis was used when two variables were not in normal distribution.P values < 0.05 were considered as statistically significant.Results:1 There were no significant differences in demographics(age,gender,BMI,SBP,smoking history,hypertension history,diabetes history,GLU,TG,TC,HDL-C,LDL-C)and final diagnosis among the three groups(P>0.05);2 There were no significant differences in levels of Hs-CRP before and 24 h,72h after PCI respectively,compared in each group and among three groups(P>0.05);3 The comparison of Lp-PLA2 levels in the three groups3.1 Among the three groups,the levels of Lp-PLA2 were no significant differences before PCI(P>0.05);Lp-PLA2 levels among the three groups were no significant differences at 24 h after PCI(P>0.05);there were no significant differences at 72 h after PCI between conventional-dose group of rosuvastain and conventional-dose group of atorvastain(P>0.05),but the Lp-PLA2 levels in intensive-dose group of rosuvastain were significantly decreased,compared with rosuvastain group and atorvastain group which received conventional-dose respectively(P<0.05);3.2 24 h after PCI,Lp-PLA2 levels of the three groups were all higher than baseline levels(P<0.05);the levels of Lp-PLA2 at 72 h after PCI were higher than the baseline levels in routine dose group of rosuvastain and atorvastain(P<0.05);in intensive dose group of rosuvastain,there were no significant differences compared with the preoperative levels(P>0.05);72h after PCI,the Lp-PLA2 levels were lower than that at 24 h after PCI in intensive dose group of rosuvastain(P<0.05),but the concentrations were no significant differences in routine dose group of rosuvastain and atorvastain(P>0.05);4 The plasma levels of Lp-PLA2 were positive correlation with Gensini score about coronary artery lesions in patients with ACS(r=0.355,P=0.001);5 There were no relationship between the serum levels of Hs-CRP and the Gensini score about coronary artery lesions in patients with ACS(P>0.05).Conclusion:1 Compared with serum Hs-CRP,the plasma levels of Lp-PLA2 were more reflective of the vascular damage,inflammation reaction and the variation of the plaque stability caused by PCI in patients with ACS.2 Intensive-dose rosuvastain had a better anti-inflammatory effect than conventional-dose rosuvastatin and atorvastain.3 The plasma levels of Lp-PLA2 were positive correlation with coronary artery lesions in patients with ACS. |
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