The Modification Of MoS₂ And GO With PEG And Their Application In Detecting H₂O₂ And Carrying Zinc

With the progress of science and technology and the rapid development of industrialization,more and more pollutants have been discharged into the environment.Some pollutants will produce hydroxyl radicals when exposed to the human body,which may cause oxidative damage of DNA and then lead to a series of diseases including cancers.It is of great significance in the detection of hydrogen peroxide because it can be used as a biomarker for oxidative damage in DNA.In recent years,colorimetric detection of hydrogen peroxide based on the enzyme catalytic activity of MoS₂ has been developed rapidly.However,MoS₂ bulk is cytotoxic and not dispersible in water,which hinders the further application of the material.In view of the above problems,MoS₂ has been modified in this paper to make up for the deficiencies.In addition,the modified MoS₂ has been successfully applied to the colorimetric detection of hydrogen peroxide.Based on that,GO has been modified similarly and its application in zinc carrier is explored.In view of the above two points,the main content of this paper is as follows:?1?By modifying PEG,the water dispersiblity of MoS₂ was improved and the cytotoxicity was decreased.At the same time,the catalytic activity of MoS₂ was enhanced and the H₂O₂ colorimetric sensing system is constructed based on PEG-MoS₂.In this paper,MoS₂ was prepared by a simple liquid phase stripping method.After that,PEG was modified on the surface of MoS₂ by Mo-S bond,reparing PEG-MoS₂ nanosheets with high water solubility and low cytotoxicity.The absorbance values showed a good linear relationship with the concentrations of H₂O₂ in a certain range.For PEG-MoS₂,the detection limit was 1.18 ?M and the detection range is 2.86-286 ?M under the optimal conditions.And the detection limit is almost the same with other enzyme materials based MoS₂.More importantly,PEG-MoS₂ nanosheets have better water solubility and lower toxicity,which is expected to be applied to the analysis and detection of H₂O₂ in biological samples.?2?PEG-GO nanosheets were synthesized and the morphology and structure of the material before and after the modification of PEG were compared.On this basis,take PEG-GO as the carrier and zinc as the target to construct the Zn²⁺ delivery system.After that,the release property of Zn²⁺ depened on pH in this system was explored.