Clinical Analysis Of Breast Ultrasound False Negative Breast Cancer

Objective Retrospectively analyzed the difference between false negative and true polarity of breast ultrasonography,and summarized the common clinical characteristics of such cases.To provide reference for clinicians in the diagnosis and treatment of breast cancer.Method A total of 649 patients with primary breast cancer who underwent surgical treatment and pathologic examination were enrolled in the Department of Cancer Surgery from Affiliated Hospital of North China University of Science and Technology from January 2006 to December 2015.Preoperative mammography and ultrasonography were performed before and Without any treatment,according to its preoperative ultrasound performance,divided into false negative group and true positive group.To analyze the relationship between age,menopause,lesion,lesion size,pathological type,molecular type,immunohistochemistry and lymph node metastasis and the relationship between breast ultrasonography and breast cancer in the two groups.In order to find out the impact of breast ultrasound on the occurrence of false negative factors,can be helpful for the diagnosis and treatment of breast cancer.Results The proportion of false negative in breast ultrasound was 6.6%(43/649)in 649 patients with breast cancer.In the univariate analysis,the proportion of young people(?44 years)in the false negative group was 20.9%(9/43)higher than that in the true positive group(51/606),and the difference was statistically significant(X2=7.514 P=0.023).The proportion of the quadrant was 32.6%(14/43),23.3%(10/43)and 7.0%(3/43)in the negative control group were higher than those in the true positive group(72/606),18.3%(111/606),4.0%(24/606),especially the areola area,the difference was statistically significant(X2 =19.042 P=0.001).The(2/43)and 58.1%(25/43)were higher than those in the true-positive group(0/606),44.1%(267/606)),The difference was statistically significant(X2=33.607 P=0.000).There was no statistically significant difference between the two groups in menopause,lymph node metastasis,pathological type,molecular typing and immunohistochemistry and mammography.The P values were all greater than0.05.In multivariate analysis,age,lesion site and lesion size were the factors that produced false negative ultrasound.The younger the more prone to false negative;compared with the inner quadrant,areola prone to false negative results;the smaller the more prone to false negative lesions.Conclusions The results of univariate analysis showed that the false negative was related to the age,size and location of the lesions:Youth(?44 years)than in the elderly patients more prone to breast ultrasound false negative;Tumor size of Tis and T1 stage is prone to false negative breast ultrasound;Tumor located in the areola area,within the next quadrant,the upper quadrant prone to breast false negative;Menopausal status,lymph node metastasis,pathological type,molecular type,immunohistochemistry and breast ultrasound false negative no significant relationship.Multivariate analysis showed that the age,location and size of the final independent variables were entered into the model.Age is a protective factor for false negative results,the younger the more prone to false negative;location is a risk factor for false negative results,compared with the inner quadrant,areola area prone to false negative results;lesion size is a protective factor for false negative results,more small lesions prone to false negative.