Expression And Significance Of Osteopontin And CD133 In Ovarian Epithelial Carcinoma

Objective Using immunohistochemical method to detect osteopontin(osteopotin,OPN)and the expression of CD133 in epithelial ovarian cancer,and analyze their correlation with clinicopathological parameters and biological significance.Methods immunohistochemistry was used to detect osteopontin and CDl33 in benign,borderline and malignant tumor tissues and normal ovarian tissue.Results OPN mainly in the ovarian cancer cell cytoplasm coloring,part of the cell membrane coloring,brown or brown particles,the distribution was focal or flaky,interstitial cells were almost no color or light color.Cell membrane and cytoplasm appears brown particles are CDl33 protein staining positive performance,mainly expressed in ovarian cancer cells.The positive expression of OPN and CD133 the difference between borderline tumors and in normal controls and benign tumors and ovarian cancer group was statistically significant(P<0.05),no statistically significant difference between normal group and benign tumor group(P>0.05);Clinical OPN,CD133 positive expression and ovarian tumor stage and differentiation and lymph node metastasis,the difference was statistically significant(P<0.05),has nothing to do with epithelial tumor histological types,the difference was not statistically significant(P>0.05);the paired data correlation analysis showed that there was a positive correlation between the expression of OPN with CD133(r=0.525,P<0.05).Conclusion OPN and CD133 were overexpressed in ovarian epithelial carcinoma and were correlated with clinical stage,grade and lymph node metastasis.There was no correlation between OPN and CD133.The expression of OPN in ovarian cancer was positively correlated with CD133,suggesting that the synergistic effect of OPN and CD133 may play an important role in the progression of ovarian cancer.