The Correlation Of Ultrasound Elasticity With The Immunohistochemistry In Non-mass-like Breast Cancer

Objective: Analysis about Characteristics of conventional ultrasound and elastography,Combined with immunohistochemical results,Study its correlation,To provide a new basis for early diagnosis,treatment and prognosis of Non-mass-like breast cancer.Methods:To collect 30 patients with pathologically confirmed breast cancer and ultrasound showed non mass type.Records of their Conventional ultrasonography(Location,size,Boundary,Blood flow,Blood flow resistance index,Echo,etc.).Record SR?Elastography score,Combined with the characteristics of UE and immunohisto-chemical results(ER?PR?HER-2?P53),Analyze its correlation.Result: The UE grading is correlative to the expression of ER(P<0.05),The UE grading is correlative to the expression of PR(P<0.05),The UE grading has no correlation to the expression of HER-2(P>0.05),The UE grading is correlative to the expression of P53(P<0.05),The ER?PRpositive expression rates of the 4 to 5 group is higher than the rate of 1-3 group.The P53 positive rates of the 4 to 5 group is lower than the rate of 1 to 3 group.SR is correlative to the expression of ER(P<0.05),SR is correlative to the expression of PR(P<0.05),SR is correlative to the expression of HER-2(P<0.05),SR is correlative to the expression of P53(P<0.05),The PR positive rates of the group whitch SR ?3.0 is lower than the group that SR<3.0.The ER?Her-2?P53 positive rates of the group whitch SR ?3.0 is higher than the group that SR<3.0.Conclusion: 1.The Ultrasound elasticity of the Non-mass-like breast cancer is correlative to the expression of the immune factors ER?PR?P53,and help in the treatment and prognosis of the Non-mass-like breast cancer.2.If the Non-mass-like breast cancer's grade of elasticity is higher than the third grade,the ER?PR positive expression rates will be higher,the P53 positive expression rates will be lower which is more suitable for endocrine therapy and the prognosis is significantly better after treatment.3.If the Non-mass-like breast cancer's SR ?3.0,the PR positive rates will be lower,the ER?Her-2?P53 positive rates will be higher which is not suitable for endocrine therapy and the prognosis is poor.