Efficacy Of Coenzyme Q10 In Preventing Propofol Infusion Syndrome In Rats

Objective:To evaluate the efficacy of coenzyme Q10 in preventing propofol infusion syndrome in rats.Methods:Thirty pathogen-free male Sprague-Dawley rats,aged 8^-10 weeks,weighing 250-280 g,were randomly divided into 3 groups?n=10 each?using a random number table: control group?group C?,propofol group?group P?and coenzyme Q10 group?group CoQ10?.Normal saline was infused intravenously in group C.In group P,1% propofol in medium-and long-chain triglyceride emulsion injection was infused intravenously.In group CoQ10,CoQ10 100 mg/kg was administrated by intragastric gavage,and 1 h later propofol was infused intravenously.The infusion rate was 20 mg·kg^-1·h^-1 within the first 6 h and 40 mg·kg^-1·h^-1 for the rest 6 h,and the total time was 12 h in the three groups.Immediately after the start of administration?T0?,and at 6 and 12 h after the start of administration?T1,2?,blood samples 2 ml were taken from the common carotid artery,with 0.5 ml for blood gas analysis and 1.5 ml for determination of the levels of serum aspartate aminotransferase?AST?,alanine aminotransferase?ALT?,creatine kinase?CK?,creatine kinase isoenzyme-MB?CK-MB?,cardiac troponin I?cTn I?,blood urea nitrogen?BUN?and creatinine?Cr?.After blood sampling,the rats were sacrificed,and myocardial tissues were obtained for pathological examination.Results:Compared with group C,the serum AST,ALT,CK,CK-MB and cTnI levels were significantly increased at T1,2?P<0.05?,no significant changes were found in serum BUN and Cr levels?P>0.05?,the pathological changes of myocardium were aggravated in P and CoQ10 groups.Compared with group P,the serum AST,ALT,CK,CK-MB and cTnI levels were significantly decreased at T1,2?P<0.05?,no significant changes were found in serum BUN and Cr levels?P>0.05?,and the pathological changes of myocardium were attenuated in group CoQ10.Conclusion:Coenzyme Q10 can effectively prevent the development of propofol infusion syndrome in rats.