| Objective: Along with the social aging degree aggravating,the prevalence of the T2 DM is steadily increasing.T2 DM caused by systematic vascular pathological change and general multiple organ damage,cranial nerve function damage is one of them.This study using a multiple of MRI sequences which include normal MR conventional and fMRI sequences.Through this stduy,we preliminary discussion on the cerebral microstructure damage in patients with T2 DM,probing the value of combination multiple of MRI sequences and provide the medical image of early medical diagnoses on microstructural damage in paitients with Type 2 Diabetes Mellitus.Materials and methods: Selection to 45 cases of T2 DM patients in the No.1hospital of lanzhou university hospital,who are diagnosed with T2 DM from endocrinology department during Mar.2016 to Dec.2016.According to their degree of diabetic retinopathy in group A(NPDR group)and group B(PDR group),group A have 9 male and 13 female,group B have 11 male and 12 female.The study also set up healthy controls group C(HC group)and have 9 male and 9 female.All of the above selected object have used MRI scans of brain which include T1 WI,T2WI,DWI,SWI and DKI sequences.A total of the ROI have nine areas,cortex-subcortical area include FLWM,PLWM,TLWM and HIP;basal ganglia and thalamus areas include GP,PU,CN and THA;cerebellum brainstem area include SN.Analyze the data between different groups and calculate P values to evaluate their differences.Chi-square test is used to analyze the count data between the two groups and Independent samples t-test is used to analyze measurement data between the two groups.When P < 0.05,we think to the comparison data has obvious differences and statistically significant.Results:1.Comparing with group A and group C,we can see that the TLWM,GP,PU and the HIP have statistically significant difference.Comparing with group A and group B,we can see that the SN and the PU have statistically significant difference.Comparing with group B and group C,we can see that the SN,TLWM,PLWM,HIP,GP,PU and THA have statistically significant difference.2.Comparing with group A and group C,we can see that the HIP,PU,and CNhave statistically significant difference.Comparing with group A and group B,we can see that the TLWM,SN,PU,CN and THA have statistically significant difference.Comparing with group B and group C,we can see that the SN,FLWM,TLWM,HIP,PU,CN and THA have statistically significant difference.3.Comparing with group A and group C,we can see that all of the ROI have no statistically significant difference.Comparing with group A and group B,we can see that the FLWM,HIP,SN have statistically significant difference.Comparing with group B and group C,we can see that the SN,FLWM,TLWM,HIP,PU,CN and THA have statistically significant difference.4.To comparison between the T1 WI,T2WI,DWI and SWI sequences of MRI scans in the CMBs detection rate of T2 DM.The results show that T1 WI and T2 WI sequences have no statistically significant difference,DWI sequences have statistically significant difference with T1 WI and T2 WI,SWI sequences have statistically significant difference with T1 WI,T2WI and DWI sequences.5.To analysis the predilection site of CMBs in group A,group B and group C.The results show that,the most predilection site of CMBs is cortex and subcortical area,and then is basal ganglia and thalamus,and then is cerebellum brainstem area.6.Comparing with group A and group C,we can see that the HIP and SN have statistically significant difference.Comparing with group A and group B,we can see that the SN,GP and CN have statistically significant difference.Comparing with group B and group C,we can see that the FLWM,HIP,SN,GP,PU and CN have statistically significant difference.Conclusion:1.DWI and SWI sequences are both have a very accurate reflection on CMD in T2 DM.Both of them have correlation in the aspect of evaluation on CMD in T2 DM.The two kinds of technology joint application can more accurately reflect the CMD in T2 DM.This can early to assess damage degree diagnosis of CMD in T2 DM.This is good for early diagnosis and early therapy and have a positive sifnificance on slow disease progression and prognosis of T2 DM.2.The parameter value change of DKI sequence can precise reflect the CMD.From group C to group A to group B,with the degree aggravating of CMD,MK value and FA value are gradually decreasing trend while the MD value is gradually increasing trend.3.Multiple sequence in this study,the SWI sequence of MRI scan have most advantage on the susceptibility and detection rate of CMBs.The most vulnerable area of CMBs is basal ganglia and thalamus.From group C to group A to group B,SWI phase vslues is gradually decreasing trend accompanied by the degree aggravating of CMD while the content of the iron deposit is gradually increasing trend. |
