Hospitalized Patients With Eosinophilic Granulomatosis With Polyangiitis Clinical Characteristics Analysis

Objectives Explore the acidophil granulomatous vasculitis clinical features and ANCA positive and negative patients clinical characteristics,treatment and outcome of different.Methods Analysis during June 1989 to March 2015,Beijing union medical college hospital acidophil granulomatous vasculitis of hospitalized patients with clinical data,including demographic characteristics,clinical manifestation,laboratory examination,biopsy pathology,FFS score,BVAS scores,treatment,prognosis and outcome,analyzes the influential elements of the patient's prognosis and survival,on the basis of antineutrophil cytoplasm antibodies(ANCA)is divided into two groups,Analysis of ANCA positive and negative differences between patients clinical characteristics,treatment and prognosis.Results 1 A total of 209 patients with EGPA,among which 128 were male,female 81 cases,mean age 45.23±16.61 years(range 14-80 years);Male: female = 1:0.63;The median age of 45.ANCA positive patients ?65 years old were 13 cases of patients,ANCA negative patients ?65 years old were 20 patients,age of 65 or more patients with ANCA positive rate was higher(P < 0.05).2 Fever in 33 patients with clinical manifestations: ANCA positive(78.6%),fever,88 patients with ANCA negative(52.7%),ANCA fever more positive than negative patients(P<0.05).ANCA positive alveolar hemorrhage,3 Cases(7.1%)patients,patients with ANCA negative alveolar hemorrhage in 1 case(0.6%),ANCA positive than negative patients prone to alveolar hemorrhage(P< 0.05).Positive ANCA in patients with CRP average 51.59±45.60 mg/L,negative patients was 26.52±46.51 mg/L,more than two positive ANCA in patients with inflammatory reaction significantly(P < 0.05).ANCA positive patients erythrocyte sedimentation rate averages 61.91±43.05 mm/h,negative patients average 32.08±33.69mm/h,ANCA positive patients blood sedimentation with faster and more significantly(P< 0.001).ANCA positive patients with platelet average(312.69 ±130.87)× 109/L,average negative patients(253.50±126.21)× 109/L,higher platelet ANCA positive patients(P < 0.05).Patients with positive ANCA creatinine average124.35±126.98?mol/L,average negative patients 76.63±36.66?mol/L,patients with ANCA positive urine creatinine is higher(P<0.001).ANCA positive patients with urea nitrogen average 8.58±6.9mmol/L,average negative patients 5.42±2.6mmol/L,urea nitrogen values higher ANCA positive patients(P<0.001).3 ANCA positive patients is more often used hormone and cyclophosphamide combination therapy(P < 0.05),patients with ANCA negative more application hormone therapy alone(P<0.05),but the prognosis was not significantly difference(P<0.05).4 The prognosis of patients with ANCA negative associated with FFS score(P<0.05),the higher the score,the worse prognosis.Respiratory failure for the prognosis of patients with ANCA positive risk factors(P<0.001).Conclusions 1 Our hospital inpatients in patients with positive ANCA indicators at the age of 65 or higher proportion is higher.2 ANCA fever and alveolar hemorrhage more positive than negative patients.3 Patients with ANCA positive than negative blood sedimentation,hypersensitive c-reactive protein and blood platelet,creatinine and urea nitrogen is higher.4 Patients with positive ANCA is more often used hormone and immune inhibitors(cyclophosphamide)combination therapy,is common in patients with ANCA negative application of glucocorticoid therapy alone,its mortality did not differ between them.