Study On The Correlation Between Serum DNA Level And ALT,APRI And FIB-4 Values In Patients With Chronic Hepatitis B

ObjectBy investigating the correlation between serum HBV DNA load and alanine aminotransferase(ALT),APRI and FIB-4 values in patients with HBeAg positive and negative chronic hepatitis B(CHB),to understand the different application value of serum HBV DNA level in monitoring the progression of the disease under different HBe Ag expression status.MethodsThe basic data collected from 111 cases of patients with CHB and serum HBV DNA,alanine aminotransferase(ALT)and aspartate aminotransferase(AST),platelet(PLT)level of serological data using the formula to calculate the APRI and FIB-4 index,and alanine aminotransferase(ALT)as a marker of inflammation.The APRI and FIB-4 index as the index of liver fibrosis correlation study.The SPSS 21.0software was used to perform all statistical analyses.Graphs were processed with the GraphPad Prism 5Software.ResultsThe serum HBV DNA load of patients with HBe Ag negative CHB was lower than that of HBeAg positive CHB(Z=-3.684,P < 0.01),and no significant differences of serum ALT level and APRI value were observed between two groups(Z1=-0.968,P > 0.05;Z2=-0.808,P > 0.05).The value of FIB-4 in HBeAg negative CHB patients was higher than that of HBeAg positive CHB patients(Z=-2.266,P < 0.05).The age of HBeAg negative CHB patients was larger than that of HBe Ag positive CHB patients,and the difference was statistically significant(t=3.859,P < 0.01).The serum HBV DNA load of HBeAg negative CHB patients was positively correlated with ALT,APRI and FIB-4((r=0.347,r=0.648,r=0.596,P < 0.01).There was no correlation between serum HBV DNA load and ALT,APRI and FIB-4 values in HBeAg positive CHB patients(P > 0.05).ConclusionThe serum HBV DNA level can better reflect the degree of inflammation and fibrosis of liver tissue in patients with HBe Ag negative CHB,but can not reflect the degree of liver inflammation and fibrosis in patients with HBeAg positive CHB.