Diagnostic Value And Significance Of Urinary Insulin Like Growth Factor Binding Protein 7 In Acute Kidney Injury

Object:This experiment by observing urine IGFBP7 of patients with AKI,explores the predictive value of urine IGFBP7 in the diagnosis and treatment of AKI and providing reliable basis for the timely diagnosis of AKI and evaluation of renal function.Methods:Choosing the patients who coming from shihezi university school of medicine in the first affiliated hospital as the research object range from December 2015 to May 2016.In strict accordance with the inclusion criteria and exclusion criteria,collecting 50 patients with AKI together.The number of patients who suffer form chronic kidney diseases(CKD)is 30.The number of healthy people who have the same of gender,age,body weight is 30.Collecting the basis of the patients' date(gender,age,etc.).All entrants need save early morning urine(middle of urine)and a morning fasting blood samples in the first 24 hours.Biochemical analyzer tests serum Cystatin C(s Cys C),Serum creatinine(Scr)and using enzyme-linked immunosorbent assay(ELISA)to test the level of urine IGFBP7.Finally,arranging three groups of research data to statistical analysis.Results:1.Compared with normal group,the group of chronic kidney disease(CKD),Significantly increasing urine IGFBP7 levels of AKI group,the difference was statistically significant(P < 0.05).Compared with normal group,s Cys C levels of AKI grooup increased significantly.The difference was statistically significant(P < 0.05).Compared with the group of chronic kidney disease(CKD),s Cys C levels of AKI group are slightly higher by the group of chronic kidney disease(CKD).There was no statistically significant difference(P > 0.05).With the progress with AKI periods,urine IGFBP7 and serum s Cys C levels increased.The phase difference was statistically significant(P < 0.05).2.Linear correlation analysis showed that urine IGFBP7 and s Cys C and Scr in group of AKI were positively correlated(r=0.782,P<0.01;r=0.884,P<0.01).3.ROC curve analysis showed that In the diagnosis of AKI,urine IGFBP7 area under the curve was 0.889(95% CI 0.813 to 0.966,P < 0.01);SCys C area under the curve was 0.877(95% CI 0.803 to 0.951;P < 0.01).Conclusion: 1.Urine IGFBP7 significantly increased in patients with AKI,and had high sensitivity in the diagnosis of AKI.Therefore,urine IGFBP7 is expected to become new biological markers of AKI.2.The urine IGFBP7 with AKI progress gradually rise in every period of AKI stage and had important guiding significance.