The Effect Of Catheter Ablation And Pharmacologic Therapy On Cardiac-related Hospitalization In Hypertrophic Cardiomyopathy Patients With Atrial Fibrillation

Objective:To evaluate the effect of radiofrequency catheter ablation(RFC A)and pharmacologic therapy on cardiac-related hospitalization in hypertrophic cardiomyopathy(HCM)patients with atrial fibrillation(AF).Methods:This study enrolled forty-eight HCM patients with AF who initially underwent catheter ablation.Seventy-eight subjects who only received pharmacologic therapy were selected as the control group.AF recurrence and cardiac-related hospitalization were followed-up routinely.Results:After follow-up of(17.6 ± 8.4)months,AF recurrence occurred in 16(33.3%)patients after a single procedure.In the control group,successful restoration of sinus rhythm was achieved in 39.7%patients after an average of(10.7±8.0)months.The unplanned cardiac-related hospitalization rate was significantly lower in the RFC A group(21.8%vs.4.2%,P = 0.0013).Cox regression analysis revealed that therapeutic strategy(HR 9.082,95%CI 1.130?73.011,P = 0.038)and heart failure history(HR 2.860,95%Cl 1.072?7.633,P = 0.036)were independent risk factors of unplanned cardiac-related hospitalization.Conclusions:In HCM patients with AF,catheter ablation seems to be superior to pharmacologic therapy in sinus rhythm maintenance and unplanned cardiac-related hospitalization reduction.Therapeutic strategy and heart failure history were independent risk factors of unplanned cardiac-related hospitalization.