| The number of deaths caused by smoking is as high as 6 million every year in the world,and it has become an indisputable fact that tobacco is harmful to human health.However,the problem of smoking has shown a trend of younger age and has become increasingly prominent.Adolescents are in a critical period of growth and development.Smoking behavior will have great harm to the development of the later period.Adolescent smoking is not only a personal problem,but also a social problem to be solved.Therefore,it is of great significance to explore the underlying neural mechanism of adolescent smoking behavior.Craving and inhibition control are two core issues in the field of addiction,and play an important role in the development of addictive behavior.In this paper,we focused on the study of the neural electrophysiological indexes of adolescents with craving for abnormal cognitive processing and the inhibition of control loss.Our works were divided into two parts as follows: First,we used event-related potentials(ERP)to explore the cognitive processing bias of Craving of adolescent smokers.The P300 and SPW components among adolescent smokers(19)and healthy nonsmokers(19)were analyzed comprehensively.We found that smoking-related pictures could induce greater SPW amplitude in adolescent smoking group compared with non-smoking group.In addition,the P300/SPW amplitude induced by smoking-related pictures was significantly higher than that of neutral pictures in the adolescent smokers group.In addition,there was a significant positive correlation between P300 /SPW and the number of cigarettes per day at the Fz and Cz in the adolescent smokers group.Second,this paper also uses resting-state EEG technology combined with the Go/NoGo task to explore the impaired inhibitory control ability of adolescent smokers.The results showed that the delta,beta and gamma rhythm were significantly lower in adolescent smokers compared with nonsmokers.In addition,in the Go/NoGo task,adolescent smokers showed a greater number of NoGo errors.It was also noted that there was a significant negative correlation between the gamma rhythm power and the number of NoGo errors in the anterior region of adolescent smokers.Our results provide a more intuitive electrophysiological evidence for the abnormal brain neural mechanisms in adolescent smokers,and provide a new idea for the prevention,intervention and treatment of nicotine addiction. |
