Low And High EPHA4 Activate Metastasis And Growth But Inhibit Proliferation And Apoptosis Different Mechanisms Between Hepatitis/Cirrhotic Liver Tissues And HCC

The aim of thethesis is to construct and analysislow and high EPHA4 activate metastasis and growth but inhibit proliferation and apoptosis different mechanisms between Hepatitis/Cirrhotic Liver Tissues and HCC.225 significant molecules were identified from 6144 genes of random paired 25 low no-tumor hepatitis/cirrhotic tissues(HBV or HCV infection)compared with 25 high HCC in GEO data set GSE10140-10141 by SAM.Thenwe constructEPHA4-activation and-inhibitionmolecular networks in low no-tumor hepatitis/cirrhotic tissues(HBV or HCV infection)and high HCC from mutual positive correlation of the overlapping between the corresponding direct relationship by GRNInfer and Pearson,respectively.Based on integrative GO,KEGG,GenMAPP,BioCarta and disease databases,we proposehypothesesas follows:Low EPHA4 interactive neuron and inflammation-induced no-tumor hepatitis/cirrhotic tissues(HBV or HCV infection)metastasis through DDX10-CNTNAP2-HOXD4-MAP2K6;low EPHA4 inhibiting no-tumor hepatitis/cirrhotic tissuesproliferation through PSMC3IP-CCNB1-CCNE2;high EPHA4 outside-inside-out interactive neuro-induced HCC regulation of growth through ALK-C9orf127-ARHGDIG;high EPHA4 inhibiting T cell-induced HCC apoptosis through CAD-E2F1-TSTA3-MCM4-TTK.