Analysis Of Related Factors Of Amenorrhea Caused By Chemotherapy In Premenopausal Breast Cancer

Objective: CIA (chemotherapy-induced amenorrhea) is defined as 6 months from the start of chemotherapy after amenorrhea amenorrhea lasting 12 months at least. The purpose of the study is investigate the incidence and influence factors of CIA in premenopausal breast cancer patients after chemotherapy and the clinical significance of CIA in premenopausal breast cancer patientsMethods: From September 2012 to September 2013,retrospectively collected 108 new cases in Yunnan cancer hospital which were premenopausal breast cancer patients, information were collected from medical records, including the age at diagnosis, height, weight, BMI, chemotherapy regimen, chemotherapy cycles,menarche age, birth history, surgical method, tumor characteristics, clinical pathological,endocrine therapy and the use of trastuzumab, radiotherapy. The prognosis and menstrual status after chemotherapy was followed up by telephone. All statistical data were processed by SPSS24.0. The ratio of the constituent ratios of test were compared by chi square , ROC curve was used to explore the forecasting circles of CIA age and BMI value. The comparison of RM time in different age groups were compared by Kruskal-Wallis H test. Survival analysis was performed by Kaplan-Meier method, and log-rank test was used to compare the differences between groups. The correlation analysis of continuous data was carried out by Spearman correlation analysis. The correlation analysis of categorical variables was carried out by using the contingency coefficient of cross table.Results: The median follow-up time was 46 months (12-54 months). The age of patients ranged from 28-53 years old, the median age was 43 years. Most breast cancer patients are lymph node negative, hormone receptor positive, HER2 negative,and tumor diameter less than 2cm. A total of 62 patients developed CIA, and 46 did not develop CIA. A total of 56 patients recovered menstruation after chemotherapy during the follow-up period, of these, 13 did not stop menopause. Newly diagnosed age is an important prognostic factor in premenopausal breast cancer caused by chemotherapy and has an important impact on the recovery of amenorrhea. CIA risk increases in patients over 42 years of age, patients less than 44 years old are more likely to recover menstruation. The BMI value was associated with CIA, with a higher proportion of CIA in patients with BMI greater than or equal to 23. The earlier the amenorrhea is from the first chemotherapy, the more likely it is to develop CIA.Different chemotherapy regimens, tamoxifen and trastuzumab, were not found to have an impact on the incidence of CIA. There was no significant correlation between menstruation recovery time and DFS, hormone receptor and chemotherapy regimen.CIA may have a potential benefit for disease-free survival in breast cancer patients.Conclusions :Newly diagnosed age is an important prognostic factor in premenopausal breast cancer caused by chemotherapy and has an important impact on the recovery of amenorrhea. Patients over 42 years of age are at increased risk for CIA, and patients under 44 are more likely to recover from menstruation. The BMI value,the time between amenorrhea and the first chemotherapy is associated with the occurrence of CIA, CIA may have a potential benefit for disease-free survival in breast cancer patients. After chemotherapy, the patient met the criteria for menopause,but less than 44 years of age, regular monitoring of estrogen and FSH is required before and after aromatase inhibitors are used.