A Study On The Changes In Subfoveal Choroidal Thickness After Phacoemulsification In Diabetic Patients

Objective:The aim of the study was to analyze the changes of Subfoveal choroidal thickness(SFCT)after phacoemulsification surgery in diabetic patients,The relationship between the changes of SFCT and fasting blood glucose as well as glycosylated hemoglobin.Methods:In this prospective study,40 eyes of 40 patients having phacoemulsification surgery were included,20 patients with diabete as diabetic group,20 patients without diabetes as control group.Fasting blood glucose and glycosylated hemoglobin was tested in all patients before the phacoemulsification surgery.The best corrected visual acuity(BCVA)was tested preoperatively and postoperatively 1 week?1 month and 3 months by Logarithmic visual acuity chart.Statistical analysis of measurement data were done by the Mann-Whitney U test.The Subfoveal choroidal thickness was measured preoperatively and postoperatively 1 week?1 month and 3 months by enhanced depth imaging optical coherence tomography(EDI-OCT).Statistical analysis of measurement data were done separately by the variance analysis and SNK-q test.Multiple linear regression analysis was conducted to identify changes in subfoveal choroidal thickness including age?duration of diabetes?fasting blood glucose and glycosylated hemoglobin.Results:The best corrected visual acuity(BCVA)of the comparison was not statistically significant between two groups preoperatively and at the postoperative 1 month and 3 months(P>0.05).The BCVA in control group was better than that in diabetic group at the postoperative 1 week(P<0.01).Mean SFCT of diabetic group was 174.15?188.58?197.07 and 194.11 pm at the baseline and at the postoperative 1 week?1 and 3 months.Whereas,Mean SFCT of the control group was 168.26181.50?184.50 and 183.13 ?m at the baseline and at the postoperative 1 week?land 3 months respectively,With a statistically significant increase after surgery(P<0.05).Mean SFCT of diabetic group increased significantly in 1 month after surgery.The change of SFCT was correlated with the fasting blood glucose?whereas age?duration of diabetes?glycosylated hemoglobin had no significant correlations with the changes of the SFCT.Conclusions:Phacoemulsification surgery may cause significant increase in SFCT for the diabetic patients,The changes of SFCT were positively correlated with the fasting blood glucose,which is not related with the age?the duration of diabetes and the glycosylated hemoglobin.