The Medication Adherence And Disease-related Knowledge In Patients With Inflammatory Bowel Disease In Yunnan Province

Objective:The aim of this study was to investigate the current level ofmedication adherence to treatment and disease-related knowledge in patients with inflammatory bowel disease(IBD)including ulcerative colitis(UC)and crohn's disease(CD)in Yunnan province,and identify the most common influencing factors.Method:145 cases of inflammatory bowel disease,treated in Kunming medicaluniversity first affiliated hospital in Yunnan province from January 1,2015 to January 1,2017,were recruited according to the selected criteria.Using the general data questionnaire,Morisky Medication Adherence Scale-8(MMAS-8),Crohn's and colitis knowledge score(CCKNOW)to investigate and collect the relevant information.SPSS 21.0 software was used to analyse the data.Medication adherence,disease-related knowledge and its related influencing factors of IBD patients were analyzed by t test,analysis of variance,chi-square,and linear regression analysis.Results:1.A total of 86 men and 52 women completed the questionnaires,Mean age was 42.71±15.66 years(range,14 to 80 years).Ulcerative colitis was 100(72.5%)and Crohn's disease was 38(27.5%).MMAS score was 4.47±1.44(1.25?7.75)points,the UC patients' MMAS score was 4.38±1.34 points,lower than that of the CD which was 4.70±1.66 points,but there was no significant statistical hypothesis(P=0.244).It cannot say that UC patients' medication adherence was lower than patients with CD.119 patients with low medication adherence(86.2%),including 89 patients with UC(89.0%),30 patients with CD(78.9%).17 patients with medium medication adherence(12.3%),including 10 patients with UC(10.0%),7 patients with CD(18.4%).2 patients with high medication adherence(1.4%),including I patient with UC(1.0%)andl patient with CD(2.6%).2.It was found that factors associated with medication adherence were marital status(P = 0.033),knowledge level(P = 0.044),the student status(P = 0.049),understanding to the medication regimen(P = 0.016),treatment with glucocorticoids(P = 0.020).There were no differences in medication adherence for the following:gender,age,nationality,fertility status,living conditions,employment status,annual income,medical payment method,smoking,drinking.3.In this study,the average CCKNOW score was 9.23±4.65(0?21)points,among them,patients with UC was 8.81±4.66 points,patients with CD was 10.34±4.50 points.But statistical hypothesis have not reached significant level(P=0.084),it cannot say that UC patients' disease-related knowledge was lower than patients with CD.4.The results showed that marital status(P = 0.009),fertility status(P = 0.014),knowledge level(P = 0.000),the employment status(P = 0.020),understanding to the medication regimen(P = 0.003),treatment with glucocorticoids(P = 0.023),medical payment method(P = 0.025),gastrointest:inal surgery(P ? 0.027)were the main factors in patients' disease-related knowledge.The factors of gender,age,nationality,living conditions,annual income,smoking,drinking had no statistical significance.5.In a linear regression analysis,MMAS score was positively correlated with its own Crohn's and colitis knowledge score.Conclusions:1.Patients with inflammatory bowel disease(IBD)often did not take their medications as prescribed.Medication non-adherence seemed to be a particular problem in patients with inflammatory bowel disease(IBD)in Yunnan province.The factors of marital status,knowledge level,student status,understanding to the medication regimen,treatment with glucocorticoids are closely related with patients'medication adherence.Management of patients with drug using behavior,real-time assessment and tailored interventions should be given to patients in the process of treatment by doctor in digestive department.2.The patients with inflammatory bowel disease in Yunnan province had poor knowledge about the IBD,the disease-related knowledge of IBD was connected with marital status,fertility status,knowledge level,employment status,understanding to the medication regimen,treatment with glucocorticoids,medical payment method,gastrointestinal surgery.3.Related knowledge of the disease has an impact on patients' medication adherence.Improving the level of patients' disease-related knowledge and strengthening the patients' health education and self management can improve the patients' medication adherence and therefore improve health-related quality of life of patients.