| Objective:To investigate the distribution of TCM syndrome factors in patients with essential hypertension combined carotid atherosclerosis,explore the relationship of TCM syndrome factors with carotid artery stenosis and ApoE genetic polymorphism,provide evidence for clinical differentiation.Methods:According to the requirements of epidemiological investigation and the book"TCM differentiation of syndrome factors"writtened by Professor Zhu Wenfeng,we set the syndrome factors scale of the patients diagnosed hypertension combined carotid atherosclerosis(Annex 2).we collected four diagnostic information of 220 patients with hypertension combined carotid atherosclerosis and createed a database.On the basis of contribution of each symptom to syndrome factors,we calculated diagnostic value of every syndrome factors.If the value was more than or equal to 17,the patient was thought to have this syndrome factor.By using SPSS20.0,the frequency analysis was used to analyze syndrome factors,the partial correlation analysis was used to analyze the correlation between syndrome factors and carotid artery stenosis and ApoE genetic polymorphism.Results:1.The distribution of TCM syndrome factors1.1 Location of TCM syndrome factorsThe order from high to low:kidney,liver,spleen,heart,lung;The most patients located on kidney(143 cases,65.0%).1.2 Nature of syndrome fctorsThe order of single deficiency syndrome factors distribution from high to low was as follows,Yin deficiency,qi deficiency,yang deficiency and blood deficiency.The frequency of Yin deficiency was the highest(96 cases,43.6%);The order of single excess syndrome factors from high to low was as follows,phlegm,bloodstasis,qi stagnation,wetness,yang hyperactivity,heat.The frequencies of sputum,blood stasis and qi stagnation were 121 cases(55.0%),62 cases(28.7%)and 33 cases(15.0%),respectively.1.3 Miscellaneous syndrome factorsMiscellaneous location of TCM syndrome factors:The order from high to low was as follows,disease involving liver and kidney(70 cases,32.0%),disease involving spleen and kidney(50 cases,22.7%),disease involving liver and spleen(28 cases,12.7%).The order of miscellaneous deficiency syndrome factors distribution from high to low was as follows,qi and yin Deficiency(30 cases,14.0%),qi and blood deficiency(15 cases,7.0%),yin and yang deficiency(13 cases,6.0%),Yin and blood deficiency(9 cases,4.0%).The order of intermingled excess syndrome factors distribution from high to low was as follows,syndrome of intermingled phlegm and stasis(24 cases,11.0%),stagnation of qi and blood stasis(20 cases,9.0%),syndrome of qi stagnation and phlegm(11 cases,5.0%),syndrome of stagnation and blockade of phlegm-damp(8 cases,3.6%).The order of intermingled deficiency and excess syndrome factors distribution from high to low was as follows,syndrome of yin deficiency and phlegm(29 cases,13.0%),syndrome of qi deficiency and phlegm(20 cases,9.0%),syndrome of yang deficiency and phlegm(18 cases,8.0%),syndrome of yin deficiency and yang hyperactivity(13 cases,6.0%).2.The correlation research about carotid artery stenosisThere were correlated trends in carotid artery stenosis and syndrome factors of blood stasis,the age of patient,the course of the hypertension(P<0.05,r = 0.17;P<0.05,r=0.253;P<0.05,r=0.222,respectively).There was no correlation between carotid artery stenosis and ApoE genetic polymorphism,blood pressure grade(P>0.05).3.The correlation research about ApoE genetic polymorphismThe order of ApoE genetic polymorphism from high to low was as follows,E3/E3(144 cases,65%),E3/E4(39 cases,18%),E2/E3(28 cases,13%),E2/E4(6 cases,2.5%),E2/E2(2 cases,1%),E4/E4(1 case,0.5%).ApoE genetic polymorphism of patients diagnosed hypertension and carotid stenosis did not correlate with TCM syndrome factors,plaque size and the degree of stenosis(P>0.05).There was correlation trend in ApoE genetic polymorphism and LDL level(P<0.01,r=0.213).Conclusions:1.The 1st location of syndrome fctors in patients suffering from hypertension combined carotid stenosis was on kidney.The main natures of syndrome factors were phlegm,blood stasis,qi stagnation.2.The main miscellaneous syndrome factors were disease involving liver and kidney,syndrome of intermingled phlegm and stasis,qi and yin deficiency,syndrome of intermingled phlegm and stasis3.There were correlated trends between carotid artery stenosis and syndrome factor of blood stasis,the age of patient,the course of hypertemsion in patients with hypertension combined with carotid stenosis.4.There was correlated trend between ApoE genetic polymorphism and LDL level in patients with hypertension combined with carotid stenosis.ApoE genetic polymorphism was not related with syndrome factors. |
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