Significance Of Postoperative Adjuvant Radiotherapy For T1-2N1M0 Breast Cancer After Modified Radical Mastectomy

Objective:A retrospective analysis of the significance of adjuvant radiotherapy after modified radical mastectomy for T1-2N1M0 breast cancer and To determine the risk factors for recurrence and metastasis of patients,and to analyze the impact of adjuvant radiotherapy on the recurrence and metastasis of patients with these risk factors.Methods:Collected from January 1,2009 to January 1,2015 in Jiangxi Province Cancer Hospital hospital treatment of 255 cases of T1-2N1M0 breast cancer patients that conducted modified radical mastectomy,these patients are divided into radiotherapy group and non-radiotherapy group according to the radiotherapy.The significance of postoperative adjuvant radiotherapy are identified initially identified for T1-2N1M0 breast cancer patients by chi-square test.And further through the Cox proportional hazards model analysis,independent risk factors,are determined for T1-2N1M0 breast cancer.The effects of radiotherapy on the recurrence and metastasis of these patients with independent risk factors were investigated by chi-square test.At the same time,the factors in the radiotherapy group and the non-radiotherapy group were analyzed,and the effect of postoperative adjuvant radiotherapy on the recurrence and metastasis was compared indirectly.Results:1.Univariate and multivariate analysis were found that Postoperative adjuvant radiotherapy was not an independent factor for relapse and metastasis(P=0.845),but was an independent factor for local recurrence and metastasis(P=0.042).The postoperative adjuvant radiotherapy of T1-2N1M0 breast cancer can not reduce the probability of total recurrence and metastasis,but can reduce the risk of local recurrence.2.Multivariate analysis found that Number of lymph node metastases(P=0.034?P=0.008)and percentage of positive lymph node(P < 0.001 ? P < 0.001)are independent risk factors for postoperative recurrence and metastasis and local recurrence and metastasis of T1-2N1M0 breast cancer,but age,hormone receptor status and clinical staging are not the overall recurrence and metastasis and local recurrence and metastasis of independent risk factors.3.There was no significant difference in the recurrence and metastasis of 1-2lymph nodes,and there were significant differences in the three recurrence and metastasis.There was no significant difference in the recurrence and metastasis that percentage of positive lymph node is less than or equal to the 25%.There was significant difference in recurrence and metastasis of that percentage of positive lymph node is more than the 25%.4.In the non-radiotherapy group,Number of lymph node metastases(P=0.008)and percentage of positive lymph node(P=0.001)had a statistically significant effect on the recurrence and metastasis of T1-2N1M0 breast cancer,while hormone receptor status(P=0.073)? age(P=0.752)and clinical stage(P=0.830)did not show a statistically significant effect on recurrence and metastasis of T1-2N1M0 breast cancer.In the radiotherapy group,Number of lymph node metastases(P=0.603)?percentage of positive lymph node(P=0.280)?hormone receptor status(P=0.759)?age(P=0.988)and clinical stage(P=0.947)did not show a statistically significant effect on recurrence and metastasis of T1-2N1M0 breast cancer.Conclusion:1.The postoperative adjuvant radiotherapy of T1-2N1M0 breast cancer can not reduce the probability of total recurrence and metastasis,but can reduce the risk of local recurrence.2.lymph node metastasis and percentage of positive lymph node is independent risk factors,in T1-2N1M0 stage breast cancer recurrence and metastasis and local recurrence and metastasis,radiotherapy can improve recurrence and metastasis.of the patients with these risk factors...