The Development Of Mineral Disorder And The Incidence Of Cardiovascular Calcification After Renal Transplantation

Background Renal transplant recipients have the backgrounds of chronic kidney disease,malnutrition,chronic inflammation and the long-term use of hormone,which are risk factors for mineral and bone metabolism disorders.Cardiovascular calcification in kidney transp lant recipients is not uncommon,which is associated with the incidence of cardiovascular events and the mortality.However,cardiovascular calcification aggravates in 26% of recipients.Although renal function restored after renal transplantation,cardiovascular calcification may still persist and even aggravate.After renal transplantation the secondary hyperparathyroidism(SHPT)is common.Objective To explore the early development of mineral disorder and the incidence of cardiovascular calcification after renal transplantation(RT),and to explore the change of cardiovascular calcification compared to the pre-transplant.Method From November 2013 to March 2015,115 RT recipients were enrolled in this study.Laboratory/clinical data were obtained at five regular points(pre-RT,1 month,3months,6 months and 1 year post-RT)up to 1 year post RT.Result One year post-RT 53% had i PTH above levels of 65ng/ml.The percent of hypophosphatemia one month post-RT is about 80%,and the prevalence of hypercalcemia 3 months post-RT is ahout 40%.Both of them will recover to normal level.The prevalence of cardiovascular calcification is 43.5%,and the incidence of coronary artery calcification,abdominal aorta calcification and cardic valve calcification is respective ly 31.3%,22.6% and 13%.The prevalence of cardiovascular calcification in man(50%)is higher than women(30.8%).The higher age,total cholesterol and LDL-cholesterol may contribute to cardiovascular calcification.Conclusion SHPT is common in RT recipie nts.Pre-transplant regulation of SHPT is of great importance to recipients.The incidence of cardiovascular calcification 6 months after renal transplantation is low.