| Objective: In this study,we used 3.0T magnetic resonance imaging DKI technology to measure cerebral parenchyma of T2 DM with normal cognitive function,T2 DM with MCI patients and healthy controls,to investigate the value of DKI in evaluating microstructure changes in T2 DM patients with different functional status.Material and method: 33 cases with T2 DM were collected,all for MoCA evaluation,which cognitive function normal of T2 DM patients total18 cases,MCI of T2 DM patients 15 cases,respectively divided into T2 DM with normal cognitive function group and the T2 DM with MCI group,respectively referred to A group and B group;then by age,gender and the education degree match corresponding normal control group 20 cases.All subjects were performed regular head MRI sequence and DKI examination,After scanning,the images of DKI were transmitted to image post-processing workstation,we used a software named functool to deal with the images and measure the data.The value of MK,MD,AK,RK in white matter of frontal,parietal,occipital and temporal lobe,genu and splenium of corpus callosum,posterior limb of internal capsule,caput nuclei caudati,cerebral ganglia and hippocampus.The same parts ROI were measured 2-3 times,then take average as eventually measurement value,around symmetric parts measurement value take its average.Measured data were statistically analyzed by using SPSS19.0 software.Results: 1.The MK value comparison among three groups: A group compared to HC group,the MK value in A group significantly decreased inparietal lobe-WM,genu and splenium of corpus callosum;B group compared to HC group,the MK value in B group significantly decreased in frontal lobe,parietal lobe,occipital lobe-WM,genu and splenium of corpus callosum,posterior limb of internal capsule,cerebral ganglia and hippocampus;B group compared to A group,the MK value in B group significantly decreased in frontal lobe,occipital lobe,temporal lobe-WM.2.The MD value comparison among three groups: A group compared to HC group,the MD value in A group significantly increased in frontal lobe-WM;B group compared to HC group,the MK value in B group significantly increased in frontal lobe,parietal lobe-WM,caput nuclei caudati,cerebral ganglia and hippocampus;when B group compared to A group,there is no one significantly difference between two groups.3.The AK value comparison among three groups: A group compared to HC group,the AK value in A group significantly decreased in posterior limb of internal capsule,cerebral ganglia and hippocampus;B group compared to HC group,the AK value in B group significantly decreased in parietal,temporal lobe-WM,posterior limb of internal capsule,cerebral ganglia;when B group compared to A group,although the AK value in B group decreased in all ROIs,there is no one significantly difference between two groups.4.The RK value comparison among three groups: A group compared to HC group,the RK value in A group significantly decreased in temporal lobe-WM,cerebral ganglia;B group compared to HC group,the RK value in B group significantly decreased in frontal,parietal,occipital and temporal lobe-WM,genu of corpus callosum,caput nuclei caudati,cerebral ganglia and hippocampus.B group compared to A group,RK value in B group significantly decreased in parietal lobe-WM.5.Correlation analysis between DKI parameters and CoMA score of patients in group B.It was found that MK,AK and RK value of all regions basically positive correlation with the CoMA score,especially the MK value in frontal,parietal lobe-WM,splenium of corpus callosum,and the RK value in parietal,temporal lobe-WM,hippocampus is most relevant.The MD value of all regions showed a negative correlation with COMA score,especially in parietal lobe-WM and caput nuclei caudate.Conclusion: 1.the brain microstructure of T2 DM patients whose head perform negative in regular MRI scanning has a certain degree changes,It can be find and evaluated by a new MRI technology-DKI.2.DKI technology has a limited role in the identification of brain parenchyma micro damage in T2 DM patients with normal cognitive function and MCI.However,there was a good evaluation of the damage of brain parenchyma in T2 DM patients with MCI.3.Kurtosis parameter(MK,AK,RK)is more sensitive than diffusion parameter(MD)on evaluating microstructure changes.4.The MK value,MD value and RK value of the DKI parameters were significantly correlated with the clinical score of CoMA,which may be an independent parameter to evaluate the cognitive status of the patients. |
