Study On Risk Factors Of White Matter Hypertensities And Its Relation With Red Blood Cell Distribution Width

Objective Study on risk factors of white matter hypertensities and its relation with red blood cell distribution width.Methods Consecutive patients admitted to the first affiliated hospital of Guangxi Medical University who have an MRI scan between January 2015 and October 2016 were included in our study.According to the inclusion and exclusion criteria,a total of 146 consecutive individuals were enrolled in our study.All patients were divided to two groups(WMH group,n=88;non-WMH group,n=58).The data was recorded including:(1)General information:age,gender,BMI;(2)Past history:hypertention,diabetes,cerebral stroke,coronary heart disease,smoking,drinking;(3)Laboratory data:red blood cell distribution width,hemoglobin,mean red blood cell volume,white blood cell,neutrophils percentage,total cholesterol,low density lipoprotein cholesterol,high density lipoprotein cholesterol,triglyceride,homocysteine.(4)Fazekas scale was used to measure the severity of white matter hypertensities.Ttest was used in comparison of measurement data,Chi-squared test was used in comparison of categorical data.The factors statistically significant in univariate analysis(P<0.05)were included as independent variable,WMH were included as dependent variable,binary logsistic analysis was used to analyze independent risk factors of WMH;Severity of WMH was included as dependent variable,ordinal logistic regression analysis was used to evaluate independent risk factors of WMH severity.Spearman correlation analysis was used to evaluate association between severity of WMH and RDW.Pearson correlation analysis and Spearman correlation analysis was used to evaluate association between RDW and other factors.Results(1)Univariate analysis showed that patients with white matter hypertensities were statistically older(37-86 years old,64.40±10.15 vs.30-81 years old,51.50 ± 14.22)and had higher percentages of hypertention(52.8% vs.29.3%)?higher level of homocysteine(13.45±5.41 vs.11.69±4.82)and RDW(13.7% ± 1.29% vs.13.29% ± 0.83%)but lower hemoglobin(125.89±13.64 vs.131.13±11.11)compared with controls(P< 0.05).Binary regression analysis showed that age is an independent risk factor of white matter hypertensities(OR 1.080,95%CI 1.039~1.123,P=0.000).(2)Age(51.50 ± 14.22 ? 62.25 ± 9.99 ? 71.70 ± 6.84,P=0.000)?percentages of hypertention(29.3%?48.5%?70%,P=0.004)?RDW(13.29 ± 0.84 ? 13.60 ± 1.34 ? 14.05 ± 1.05,P=0.031)showed an increasing tendency when WMH severity increased,the level of hemoglobin(131.13 ± 11.11 ? 126.63 ± 13.90 ? 123.41 ± 12.70,P=0.034)showed decreasing tendency.Ordinal regression analysis showed that age was independent risk factor of WMH severity(OR 1.095,95%CI 1.057~1.135,P=0.000).(3)Spearman correlation analysis showed that RDW were positively related with severity of WMH(r=0.207,P=0.012).(4)Pearson correlation analysis showed that RDW was negatively related to Hb?MCV(r=-0.390,-0.458,respectively,P<0.05).Conclusions(1)Age is an independent risk factor of WMH and severity of WMH.(2)RDW is elevated in patients with WMH and is positively related with severity of WMH,the mechanism of RDW and WMH requires a well-designed experiment which include greater sample size to further explore.