Application Of High Frequency Ultrasound In The Diagnosis And Therapeutic Effect Of Rheumatoid Arthritis

Objective:Rheumatoid arthritis(rheumatoid arthritis,RA)is a chronic systemic inflammatory autoimmune disease characterized by synovial membrane as the primary immune response target tissue.With the repeated occurrence of the immune response in the course of RA,it is often accompanied by progressive joint dysfunction and damage as the main manifestations of the joint pathological features.So far,the etiology of RA is still exist a lot of doubt and puzzled.To establish a technique for early diagnosis of joint dysfunction and joint damage in RA patients is a problem to study RA.High frequency musculoskeletal ultrasonography can be applied to the diagnosis of joint disease.It provides an unique evaluation method for the study of the pathogenesis,diagnosis and treatment of RA patients.In particular,it can accurately obtain the corresponding data of joint lesions,and it also can evaluate the occurrence,development and outcome,as well as the further diagnosis and treatment,of RA lesions.This paper focuses on the research and application of high frequency ultrasound in the diagnosis and treatment of rheumatoid arthritis.Methods:RA criteria for the 1987 revision of the American rheumatology association,64 cases were randomly selected from January 2014 to December 2014 to accept the diagnosis and treatment in RA patients in the Second Affiliated Hospital of Zhengzhou University.A total of 64 patients with RA who were diagnosed and treated at the Second Affiliated Hospital of Zhengzhou University from January2014 to December 2014 were randomly selected based on the RA diagnostic criteria which revised by American Rheumatism Association in 1987.According to the international ultrasound standard,the ultrasound image of the knee,ankle,wrist joint were taken.Using 8 ~ 12 MHz frequency of the linear array probe for drawing.Using the same Doppler prescription parameter for detect,multi-section observation of the lesion joint bursa with or without fluid,measuring synovial thickness,assessing synovial blood flow perfusion grade.The final measurement of each data was the average value of the three times of measurements.Analyze the correlation between clinical manifestations and ultrasound performance.64 patients were treated with standard course of treatment for a period of 12 weeks,the erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)was measured on the day of admission and after treatment for 28 days.30 healthy volunteers with no joint pain and injury history were select as the control group at the same period.The ultrasound examination method and parameters of the control group is the same as experimental group.Results:1.The injure of the knee,wrist,ankle joint of the experimental group before treatment respectively was 56,28,30 cases.Compared with the control group,the ultrasound image of the injure joint of the experimental group was synovial membrane thickness,bursa fluid effusion and Color Doppler flow imaging graded increased.2.The characteristic data of the ultrasound images of the experimental group were significantly improved compared with those before treatment(P <0.05),the difference was statistically significant(P<0.05).3.The severity of joint disease and clinical manifestations were significantly correlated with the course of disease,statistically significant(P <0.05).Conclusions:1.High frequency ultrasound can find early joint injure of RA patients,it have an important application value in the diagnosis of RA.2.High-frequency ultrasound has a unique advantage in the evaluation of RA before and after treatment.It can not only accurately reflect the changes before and after treatment of joint injure changes,but also can timely assess the efficacy and state of the patient's condition.Therefor it has a bright clinical application prospects.