Effects Of Bisoprolol Combined With Rosuvastatin On Endothelial Function And Inflammation In Patients With Coronary Slow Flow

Objective: To investigate the effects of bisoprolol combined with rosuvastatin on endothelial function and inflammation in patients with coronary slow flow(CSF).Methods : Ninety CSF patients from August 2014 to October 2015 were randomly divided into control group,statin group and combined group,thirty cases in each group.The control group was given conventional therapy(aspirin100mg/d and Isosorbidemononitrate 60mg/d),statin group was given rosuvastatin 10mg/d on the basic of control group,while the combined group was given bisoprolol 5mg/d on the basic therapy of statin group.The serum concentrations of nitric oxide(NO),endothelin-1(ET-1),high-sensitivity c-reactive protein(hs-CRP),interleukin-6(IL-6)were detected before and 8 weeks after treatment.The improvement of patients with angina pectoris was evaluated.Results: After eigtht-week,the NO levels were significantly increased in combined group and statin group,while the ET-1,hs-CRP and IL-6 levels were significantly decreased than before the treatment(P<0.05).At the same time,compareing with the statin group and control group,the NO levels was increased in combined group(P<0.05),while the ET-1,hs-CRP,IL-6 levels decreased significantly(P<0.05).There was significant difference in the effective rate between the combined group(90.0%)and the statin group(83.3%),which higher than those in control group(56.7%).Conclusions: Bisoprolol combined with rosuvastatin can improve the endothelial function and anti-inflammatory in the treatment of CSF.