| Purpose In this study , 3D-pCASL MR perfusion technique is used to access the characteristics of CBF in elder men who are beyond 80 years old.Materials and Methods 52 male subjects older than 80 years old were recruited in this study,who were asymptomatic. All the subjects performed routine brain MRI examinations and 3D-pCASL sequence on a 3.0T magnetic resonance imaging system with 8 channel brain coil. Both of two post-labeling delay time (PLD=1525ms and PLD=2525ms) of 3D-pCASL were used in this study. We used SPM12 software to measure mean rCBF values of bilateral cerebral hemispheres, anterior and posterior circulation, as well as rCBF values of frontal lobe, parietal lobe, temporal lobe, occipital lobe, basal ganglia and cerebellum. Independent sample t-test was performed to evaluate (1) the difference of CBF changes of bilateral cerebral hemispheres in two PLD time; (2) the difference of CBF changes of anterior circulation and posterior circulation in two PLD time; (3) the difference of CBF changes of every other cerebral lobe when PLD time was 2525ms.Results We found that there was no significant difference in rCBF values of bilateral cerebral hemispheres with both PLD=1525ms and PLD=2525ms ( p=0.259 , p=0.630 ,respectively) .There was a significant difference in rCBF of anterior and posterior circulation with PLD= 1525ms (p=0.019) while it was out of a significant difference with PLD = 1525ms(p=0.929). Compared with other lobes, rCBF value of basal ganglia was lower (p=0.001,p=0.032, p=0.012, p=0.026, p=0.007, respectively) .There was no significant difference in rCBF values of every other cerebral lobe when PLD time was 2525ms.Conclusion 3D-pCASL technique with multiple PLD time has an advantage to access the characteristics of CBF in elder men. Based on this, a more accurate assessment of elder patients with abnormal CBF changes can be investigated. 3D-pCASL technique can also be used to provide the evidence for clinical diagnosing.Purpose This study aims to investigate the value of 3D-pCASL MR perfusion technique in evaluating posterior circulation ischemia of the elderly beyond 80 years old and to offer the evidence of PCI of the elderly for clinical diagnosis.Materials and Methods 53 male subjects older than 80 years old were recruited in this study,including 20 subjects diagnosed as PCI by clinic and other 33 who were asymptomatic. All the subjects performed routine brain MRI examinations and 3D-pCASL sequence on a 3.0T magnetic resonance imaging system with 8 channel brain coil. Both of two post-labeling delay time (PLD=1525ms and PLD=2525ms) of 3D-pCASL were used in this study to increase the accuracy of rCBF change of posterior circulation region. We used SPM12 software to measure mean rCBF values of bilateral occipital lobes and bilateral cerebellums.Independent sample t-test and rank-sum test were performed to evaluate (1) the difference of rCBF changes of anterior circulation and posterior circulation in two groups of two PLD time;(2) the difference of rCBF changes of bilateral occipital lobes and bilateral cerebellums in two groups of two PLD time; (3) the diff'erence of increment of rCBF between two PLD interval between two groups.Results We found there was a significant difference in rCBF of anterior and posterior circulation with both PLD= 1525msand PLD=2525ms in patient group while it was only with PLD=1525msin control group (p=0.000,p=0.000,p=0.025, respectively) . There was a significant difference in detecting hypo-perfusion of bilateral occipital lobes and bilateral cerebellums with 3D-pCASL (PLD=1525msand PLD=2525ms) in patient group(p=0.003, p=0.002, p=0.000, p=0.001 , p=0.000, p=0.001 , p=0.002, p=0.014,respectively).Conclusion 3D-pCASL technique is required to use multiple PLD time to diagnose PCI of the elderly because of its slower posterior circulation blood flowing; 3D-pCASLtechnique can be used to forecast posterior circulation stroke in the elderly in terms for its sensitivity to detect the decrease of CBF in posterior circulation. |
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