| Objective: To investigate the epidemiology of dyslipidemia during 2009-2013,relationship between dyslipidemia clustering cardiovascular risk factors (CRF) and major cardiovascular and cerebrovascular diseases (CVD) in elderly check-up population.Method: A large elderly population participated in a routine health check-up in the army hospital of 2009 and 2013 were collected. In the first section, total of 31382 participants in 2009 with 94.27% males and 30361 participants in 2013 with 93.49%males were enrolled to analyze the changes of main blood lipid abnormalities among five years and also perform the repeated analysis in population without drug history. In the second section, data of 30361 participants with 93.49% males was used to analyze the dyslipidemia clustering CRF (hypertension, diabetes and obesity) and its association with coronary heart disease and stroke. CVD was defined as having coronary heart disease and/or stroke.Results: The results of the first section showed that low blood HDL-C and hypertriglyceridemia were two major types of dyslipidemia in elderly men, while hypertriglyceridemia and hypercholesterolemia in elderly women. Regardless of year,prevalence of hypertriglyceridemia, hypercholesterolemia and high blood LDL-C were mostly higher in women than in men, and the prevalence of low HDL-C was higher in men (p<0.05). The prevalence of low HDL-C in men and women (2013) remarkably increased with age growing (p<0.05), while dyslipidemia prevalence in both genders and hypercholesterolemia, hypertriglyceridemia (among 60-79 years) and high LDL-C(among 70-79 years) prevalence in men significantly decreased. As for the contrast of time trends (2009 vs. 2013), the total dyslipidemia prevalence increased. In addition to men, prevalence of hypercholesterolemia, hypertriglyceridemia (among 60-79 years)and high LDL-C (among 70-79 years) showed a significant decrease, while the low HDL-C (60-79 years) prevalence increased.The results of the second section presented that prevalence of CRF clustering was remarkable, especially in men. The clustering at least two CRFs of men with dyslipidemia were 1.59 times the size of without dyslipidemia. Multivariate logistic results showed that risk of coronary heart disease strongly increased, as the number of CRF clustering in the dyslipidemia accumulated. The adjusted OR of dyslipidemia clustering none, one and two CRFs was 1.24(95%CI: 1.12-1.38), 1.78(95%CI:1.62-1.95) and 2.35(95%CI: 2.09-2.64) in men, and 0.90(95%CI: 0.64-1.26),1.42(95%CI: 1.02-1.96) and 2.15(95%CI: 1.34-3.47) in women, respectively. The same with ischemic stroke in men, with the OR of 1.02(95%CI: 0.82-1.26), 1.67 (95%CI:1.40-1.99) and 1.81(95%CI: 1.46-2.25), respectively. And association between dyslipidemia clustering CRF and stroke was also not determined.Conclusions: Gender-difference of serum lipid abnormalities and an increasing prevalence of low HDL-C were found in the male elderly population from 2009 to 2013.And dyslipidemia clustering CRF strongly increased the risk of CVD, which needs more attention to the prevention and control of its independent and joint effects. |
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