The Association Analysis Of SLC39A8 Gene With Schizophrenia In The Uygur Chinese Population

Objective:To investigate whether SLC39A8 gene single nucleotide polymorphism?SNP?is a susceptibility SNP for schizophrenia in the Uygur Chinese population of XinJiang Province.Methods: We carried out a case-control study of 985 Uyghur patients with schizophrenia and 1218 non schizophrenia Uyghur controls.The SNP rs13107325 in the SLC39A8 gene is genotyped in all samples.Results: We found that rs13107325 was associated with schizophrenia(P_allele=0.018,P_genotype=0.0004,odds ratio?OR?=1.310,95%CI=1.048-1.650).The genotype C/T?P=0.735,OR=0.958,95%CI=0.757-1.241?and genotype C/C?P=0.261,OR=0.981,95%CI=0.949-1.014?had no relationship on schizophrenia.The allele C?P=0.018,OR=0.760,95%CI=0.604-0.955?were negative associate with the onset of schizophrenia,however,the genotype T/T?P=0.0004,OR=4.28,95%CI=1.913-9.186?and allele T?P=0.018,OR=1.310,95%CI=1.044-1.594?were related to the onset of schizophrenia.Conclusion: Our findings support SLC39A8 gene being a risk gene for schizophrenia in the Uygur Chinese population.