The Predictive Value Of Monocyte To HDL Cholesterol Ratio Level For Slow Coronary Flow

Objective:To investigate the relationship between the ratio of plasma monocyte count to high density lipoprotein cholesterol and slow coronary flow.Methods: We choose patients of cardiac centre accepted coronary artery angiography in 1st affiliated hospital of Xinjiang Medical University from January 2014 to December 2016.457 patients with coronary artery slow blood flow showed in angioraphy were defined as case group,while 503 patients with complaint of chest pain without stenosis and slow blood flow in angiography as control group.The peripheral blood leukocyte count and classification,fasting blood glucose,blood lipid,liver and kidney function were detected and BMI,MHR,platelet and lymphocytes ratio(PLR)were calculated.The ROC curve was used to determine the critical value of MHR in predicting the incidence of SCF.The thresholds were divided into low MHR group and high MHR,the difference between the two groups was compared,and the multivariate logistic regression analysis was used to analyze the risk factors of SCF.Results:Compared with the control group,the differences of age,body weight,pulse,mean platelet volume,creatinine,fasting blood glucose,triglyceride,MHR and BMI were statistically significant(P <0.05),MHR Cut-off point is 0.29,area under ROC curve(AUC)0.561,P = 0.001.Multivariate logistic regression analysis showed that age,male,smoking,hypertension,diabetes mellitus,uric acid and MHR were risk factors of SCF.The risk of SCF in high MHR group was 1.69 times higher than that in MHR group,MHR(OR = 1.69,CI 95% 1.20 to 2.38,P <0.01).Conclusion: MHR is an independent risk factor for the pathogenesis of SCF.MHR level is predictive of the incidence of SCF.With the increase of MHR level,the risk of SCF is significantly increased.