Study On The Risk Factors Of Papillary Thyroid Microcarcinoma And The Lateral Lymph Node Metastasis Of PTC

Objective:To analyze the clinical pathological characteristics of micro thyroid nodules and lateral lymph node metastasis in order to improve the diagnosis and treatment,and to timely detect thyroid microcarcinoma(TMC).Methods: A retrospective analysis of 108 patients with thyroid nodules who underwent ultrasound examination from the Affiliated Hospital of Xinjiang Medical University between January 2011 and December 2013 and were diagnosed as grade 3 or 4a according to TI-RADS grading standards.After clinic and phone call follow-up till September 2015,disease conditions of patients at the end of follow-up were taken as the outcome events of statistical analysis,developing to TMC or benign micro thyroid nodule.The following details were recorded : gender,age,if combined with other thyroid diseases when discovered firstly through ultrasound,numbers of nodule,if it was multicenter tumor,TI-RADS grading and if taking TSH regularly,analyzing its relevance to TMC.Retrospective analysis of clinical data of Ki-67,the expression of CD56,CK19 and region Ⅵ lymph nodes and the relation between the number of lateral lymph node metastasis Results: There were disease progression for 23 cases during follow-up and they were diagnosed as TMC after surgery.Differences regarding gender,age,number of nodule,if it was multicenter tumor and TI-RADS grading between TMC and benign thyroid micro nodule were of statistical significance(P<0.05);differences regarding if combined with other thyroid diseases and if taking TSH regularly between them were of no statistical significance(P>0.05).Multivariste Logistic regression analysis showed that male,multiple nodules,multicenter tumor and 4a grade according to TI-RADS grading were influencing factors for TMC.ymph nodes metastasis number ≥ 5 of that of lateral lymph node metastasis was statistically significant(P <0.05).Conclusion: Male,multiple nodules,multicenter tumor and 4a grade according toTI-RADS grading are closely related to TMC.High risk factors patients with micro thyroid nodules should be treated with active operation and those patients shall not be taken as long-term follow-up objects.Region Ⅵ lymph nodes metastasis number ≥ 5 of the patients should be considered early lateral neck dissection...