Preparation Of Graphene Nanocomposite And Its Application In Drug Sensing Performance

Drug analysis plays an important role in drug quality control,and has a great impact on human health.The vast majority of drug molecules have an electrochemical response on the electrode surface.Electrochemical technology can be applied to the analysis of drugs because it is simple,accurate,high sensitivity,low detection limit.Nanomaterials possess many remarkable properties,especially two-dimensional graphene material in recent years.It has the advantages of high specific surface area and thermal stability,good electron conduction and mechanical properties.Based on the graphene oxide,different nanocomposites are prepared as electrochemical modifiers,and they are applied to construct electrochemical sensors for drug analysis.Therefore,this paper aims at the preparation of graphene nanocomposites based on graphene oxide to build different electrochemical sensors for drug sensing,the specific works are as follows:1.Sulfosalicylic acid and graphene oxide are as raw materials.One-step electrochemical reduction method is used to reduce the graphene oxide to graphene,and the sulfosalicylic acid is polymerized at the same time.Then the acetaminophen is detected with electrochemical method.The results show that the proposed electrode(PSA/rGO/GCE)can significantly improve the electrocatalytic activity of acetaminophen.2.The graphene oxide is reduced using poly(diallyldimethylammonium chloride)(PDDA)under the microwave-assisted conditions,PDDA-GN/DNA/GCE biosensor is constructed by dropping the appropriate amount of DNA assemblies(mainly containing double helix and hairpin structures)on the surface of PDDA-functionalized graphene.This fabricated biosensor can improve the electrocatalytic response of metronidazole,and displays wider detection range,lower detection limit,excellent selectivity and repeatability under the optimum experimental conditions.Furthermore,this biosensor is applied to detect metronidazole in urine and lake water with satisfactory results,and it holds great potential in electrocatalytic and biosensing applications.3.The rGO/ML/GCE electrochemical sensor is prepared by hydrothermal synthesis with the raw materials of maltose and graphene oxide to determinate levofloxacin.Results show that the rGO/ML/GCE has remarkable catalytic effect on levofloxacin.At the same time,it possesses wider detection range,lower detection limit,reproducibility,stability and selectivity under the optimized conditions.Meanwhile,the rGO/ML/GCE is demonstrated in human urine and serum with satisfactory results.