| Purpose:To observe the effect of Yujinfang on the median survival progression and the level of CEA,CA125 and CA724 in patients with advanced stage of non-small cell lung cancer,and to explore the effect of Yujinfang on advanced non-small cell Lung cancer,phlegm-dampness lung patients with significant therapeutic effect.Method:sixty patients in the middle and late stage non-small cell lung cancer who were treated with tumor in the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from September 2015 to April 2016 were randomly divided into two groups,Each group of 30 cases.All patients were diagnosed by pathology.The experimental group of oral administration of jade side of the joint intravenous injection of Kang Lai Te injection,the specific method of treatment for the side of a Yujinfang,water decoction juice 300ml,divided into 2 bags,the patients were before breakfast,2 hours before going to bed warm clothes,1 bag/time,2 times/day,even for 3 weeks,rest 1 week,while intravenous infusion of Kang Lai Te injection 200ml/time,1/day;control group only intravenous injection of Kang Lai Te injection,the specific medication The method is 200ml/time,1 time/day.Continuous intravenous infusion of 3 weeks,rest 1 week,28 days for a cycle,continuous treatment for 6 cycles.Every three months to review and follow-up,observe and compare the two groups of patients with no progress in the length of life and tumor markers changes.Result:1.The median time to progression was 5.80 months in the experimental group and 4.50 months in the control group,P<0.05,the difference was statistically significant.2.Compared with the control group,the levels of CEA,CA125 and CA724 in the experimental group and the control group showed a decreasing trend.The levels of CEA and CA724 in the experimental group were significantly lower than those in the control group at the 3rd,6th and 9th month after treatment is statistically significant(P<0.05).3.After treatment for 3 months,the serum CA125 level in the experimental group was not significantly different from that in the control group,P>0.05,which was not statistically significant.4.The level of serum CA125 in the 6 months and 9 months after treatment was significantly different from that in the control group(P<0.05).5.There was no significant difference between the experimental group and the control group at the third month after treatment(P>0.05).After 6 months and 9 months after treatment,the difference of TCM syndromes between the experimental group and the control group Was statistically significant(P<0.05).In conclusion:1.Yujinfang can prolong the median progression of advanced non-small cell lung cancer(phlegm-dampness-lung)patients;2.Yujinfang can significantly reduce the expression of CEA,CA125 and CA724 in serum of tumor cells in patients with advanced non-small cell lung cancer(phlegm-dampness)3.Yujinfang can effectively improve the clinical symptoms of patients with advanced non-small cell lung cancer(phlegm-dampness-lung type)and reduce the TCM syndrome score. |
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