| Objective:To retrospectively analyze the clinical data of 556 children with Kawasaki disease,summarize their epidemiological characteristics and clinical features,summarize the characteristics of incomplete Kawasaki disease,IVIG nonresponsive Kawasaki disease and Kawasaki disease with CAL The clinical diagnosis and treatment to provide a reference.Methods:A retrospective analysis of 556 cases of children with diagnosis of Kawasaki disease was conducted from January 2009 to December 2014 at the First Hospital of Bethune,Jilin University.According to whether the clinical manifestations were typical,the reactivity to IVIG,whether to merge CAL Divided into three groups,respectively,from the general characteristics,clinical manifestations and laboratory data and other aspects of statistical analysis.Results:1.The incidence of KD was increasing gradually.The age of boys was more than that of girls.The ratio of male to female was 1.47: 1,the median age was 20 months,and the high incidence age was 2 years old.4-8 months for the peak incidence,in November a small peak,so the incidence of spring and summer higher.2.The incidence of clinical manifestations was as follows: fever was 556 cases(100%),lips and oral changes in 514 cases(92.4%),conjunctival hyperemia 507 cases(91.2%),extremities changes 434 cases(78.1%),416 cases of rash(74.8%),371 cases of cervical lymph nodes(66.7%),178 cases(32.0%)of perianal peeling,24 cases(4.3%)of card scars,206 cases(37.05%).3.The age of children was divided into ~ 1 year old,~ 3 years old,>3 years old,in the complete KD and incomplete KD between the two groups of statistical analysis,the difference was statistically significant(P<0.05).4.The duration of fever in IVIG nonresponders is longer than IVIG sensitives,the changes of extremities in IVIG nonresponders is higher than IVIG sesitives group(P<0.05);The percentage of neutrophils in IVIG group was significantly higher than that in IVIG sensitive group(P<0.05).The percentage of neutrophils in IVIG group was significantly higher than that in IVIG group(P <0.05).The levels of hemoglobin and albumin in nonresponders group were lower than those in IVIG sensitive group(P <0.05),and the difference was statistically significant(P <0.05).Univariate analysis of statistically significant indicators of fever,albumin,and IVIG nonresponsiveness logistic multivariate regression analysis,suggesting that fever time is longer when IVIG risk factors.5.There were 206 cases(37.05%)in CAL group,138 cases(67%)and 68 cases(33%),the difference was statistically significant(P <0.05).All the children were divided into 1 year old,~ 3 years old,> 3 years old age in CAL and n CAL between the two groups,within 1 year of age with the highest incidence of CAL,the difference between the age group was statistically significant P <0.05).The clinical manifestations of the two groups were significantly higher than those of the CAL group(P <0.05),and the other clinical manifestations were higher in the n CAL group than in the CAL group(P <0.05),except for the lymph node enlargement,The Statistical analysis of the two groups of laboratory indicators showed that CAL group hemoglobin,albumin were lower than n CAL group,the difference was statistically significant(P <0.05).Multivariate logisticregression analysis showed that age ? 1 year old,boys,longer duration of fever,albumin reduction was a risk factor for combining CALs with univariate analysis of statistically significant gender,age,fever,HGB,and albumin.Conclusion:1.KD incidence was increasing year by year,high incidence of age within 2 years,boys more common,more common in the spring and summer(April-August).2.Incomplete Kawasaki disease occurred in less than 1 year old.3.The duration of fever was independent of IVIG nonresponsiveness.4.Boys,age ? 1 year,longer duration of fever,CRP increased,albumin reduced to merge CAL independent risk factors. |
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