The Function Of SOCS Protein During Enterovirus Virus Infection

EV71 is a kind of enterovirus and the viral particles are spherical,symmetric structure of the icosahedron.The genetic materials are single strand RNA and contain one open reading frame only.The virus often occurs in infants and young children,which mostly causes self-limiting disease.But a small number of strains can cause serious neurological diseases,so the studies about pathogenesis of the virus and anti-virus targets research seems important.Suppressor of cytokine signaling(SOCS)can stimulate >30 cytokines,including leukemia inhibitory factor,granulocyte-colony stimulating factor,interleukin-6,interleukin-10,and interferon-?.During viral infection,the virus can “hijack” SOCS proteins to regulate T-cell differentiation as well as JAK-STAT and NF-?B anti-virus signaling pathways.We discuss the role and the mechanism of SOCS protein in regulating the process of enterovirus infection in this article.The aim of this study was to investigate whether SOCS protein was associated with viral infection in vitro(RD cells)and in vivo(neonatal muscle tissue and blood).In infected RD cells,we investigate that SOCS protein was elevated and the p STAT?pattern recognition receptor RIG1 was influenced too.With shuting down the SOCS protein,the replication of EV71 virus was down-regulating and the expression of antiviral factors,including OAS2?MX1?IL28?IL29,was higher than normal cells.And we also detected the same trend in muscle tissue of neonatal rats.The results demonstrated that EV71 will elevate the SOCS protein to reduce the expression of antiviral factors and helping infection.The SOCS protein plays an assistant role and suppress the activation of the interferon signaling pathway during viral infection.