| Subjects:To find the risk factors and distribution charactertistics in imaging of microbleeds in patient with atherosclerotic cerebral infarction,and lay the foundation of the reserch for the influence that the microbleeds make on the therapy of patient with atherosclerotic cerebral infarction.Methods:Patients with SWI were collected from the Department of Neutology,China-Japan Union hospital of Ji Lin University from September,2014 to December,2016.In accordance with the type of atherosclerotic thrombotic cerebral infarction and no serious medical illness patients were randomly selected from the it,exclude other patients who causes of cerebral infarction type,cerebral hemorrhage,intracranial lesions.A total of 60 clinic retrospective cases with CT,MRI,SWI imaging data and other relevant clinical data were collected,of which 35 cases had CMBs,25 cases in contral group(non CMBs cases).The statistic of basic information(demographic characteristic and so on),past medical history,personal history,laboratory results were performed by EXCEL and SPSS software.Statistical analysis were peformed in the two groups of data,in line with the normal distribution of the measured data using independent sample t test,multiple sets of data using the analysis of variance,non normal distribution of the measured data using Wilcoxon rank sum test.Count data were compared between groups using X2 test,the odds ratio was compared;correlation analysis using Logistic regression analysis,independent risk factors for Spearman correlation analysis.There is statistically significant difference between two groups when P<0.05.Results:1.We divide the patients with Atherosclerotic cerebral infarction into CMBs group and without CMBs group,compared the clinical characteristics of the two groups:The average value of triglyceride,low density lipoprotein cholesterol,hypertension prevalence rate of CMBs group was higher than that non CMBs group,the difference between the two groups was statistically significant(P = 0.001<0.05,<0.001,0.01<0.05).The lacunar infarction count,the degree of leukoaraiosis scores of CMBs group is more than non CMBs group(P=0.004<0.05),the difference was statistically significant.The data of two groups of clinical data were statistically analyzed by Logistic multivariate regression analysis.We found that LDL,the degreeof leukoaraiosis,the number of lacunar infarction was independent risk factors of atherosclerotic thrombotic cerebral infarction with CMBs,there is significant correlation between them(P=0.006,0.5,0.001,all<0.05).Spearman correlation analysis was conducted for the independent variables,we found that low density lipoprotein cholesterol,the number of lacunar infarction,severity of cerebral white matter lesion was positively related to the severity of CMBs(r=0.451,0.061,0.309,P<0.05).2.Study on the CMBs distribution characteristics in the images of CMBs patient with atherosclerotic cerebral infarction.The CMBs’ cortex distribution of CMBs patient with atherosclerotic cerebral infarction was affected by age,the older,the higher the prevalence of CMBs in cerebral cortex(P=0.043<0.05).Homocysteine,brain white matter severity of lacunar infarction count are independent risk factors of thalamus distribution in CMBs,Homocysteine is higher,cerebral white matter lesions more serious,lacunar infarction count more,the higher the prevalence rate in thalamic areas of CMBs(P=0.019、0.041、0.042,<0.05).The distribution of CMBs is related to the count of brainstem lacunar infarction(P=0.024<0.05).History of hypertension is a risk factor for CMBs in basal ganglia(P=0.036<0.05).Cerebellar lacunar infarction counts have effect on the distribution of CMBs in Cerebellum(P=0.015<0.05).Conclusion:We should alert that a Cerebral infarction patient is combinded with CMBs when he has one or more risk factors like higher LDL,a plenty of lacunar infarction,severe leukoarasis,then we can perform SWI sequence in time,which will be beneficial to the formulation of antithorombotic therapy and thrombolytic therapy,and control risk factors positively.There has different risk factors between the CMBs distribution in atherosclerotic cerebral infarction patient. |
