Assessment Of DLBCL Patients By ¹⁸F-FDG PET/CT Combined With Immunohistochemical Indexes: A Pilot Study

ObjectiveThis study aimed at investigating the diagnostic value of ¹⁸F-FDG PET/CT in diffuse large B-cell lymphoma（DLBCL）patients and the correlation between lesion SUVmax and lesion volume,lymphoma stage.MethodsWe retrospectively analyzed 48 DLBCL patients who had been performed PET/CT scans before chemotherapy.Firstly,the lesion volume and the SUVmax of the total 105 lesions in the 48 patients were analyzed.Secondly,the 48 cases were divided into two groups according to the result of germinal center B（GCB）:Group A was GCB positive while Group B was GCB negative.Then the multi-factor logistic analysis was employed to evaluate the independent dangerous prognosis factors of DLBCL.ResultsAmong the 48 patients,17 patients were GCB positive and 31 patients were GCB negative.The lesion SUVmax（20.67±11.65）was positively correlative with the lesion volume（36.89±98.22）（P=0.003）.The lesion volume of primary central nervous system lymphoma was significantly smaller than the lesion volumes of high grade（P=0.018）and low grade DLBCL（P=0.010）.The positive BCL-2was an independent risk factor（P=0.045,OR=3.889）.There was no significant correlation between c-myc and the prognosis（P=0.670）.Conclusion（1）The lesion volume of DLBCL was positively correlated with SUVmax.（2）The lesion volume of primary central nervous system lymphoma was significantly smaller than the volumes of both low grade and high grade DLBCL.（3）The positive BCL-2 pathological index were the independent risk factors.There was no significant correlation between the value of c-myc and the prognosis.¹⁸F-FDG PET/CT combined with immunohistochemical indexes indeed plays an important role in DLBCL assessment.