Systematic Review On Fried Glycyrrhizae Decoction In The Treatment Of Arrhythmia

Objective: To evaluate the clinical efficacy and safety of Fried Glycyrrhizae Decoction and its addition and subtraction in the treatment of arrhythmia.Methods: A comprehensive search of randomized,controlled clinical trials was conducted on the use of Fried Glycyrrhizae Decoction(Zhigancao soup)and its addition and subtraction in the treatment of arrhythmia from January 1,2000 to December 31,2016,published in various medical journals The This study was mainly based on the full text of Chinese academic journals(CNKI),supplemented by Wanfang database,Chinese disease knowledge database,Pub Med,EMBASE,CBM.Manually retrieved related related magazines and unpublished gray literature,data incomplete contact author asked.The methodological quality of the included literature was evaluated using Cochrane Reviewers Manual version 5.0,and the data were analyzed statistically using Revman version 5.3 software.Results: A total of 92 randomized controlled trials(RCTs)were enrolled in a total of8193 patients.Included in the study of 82 cases of C grade literature,only 10 cases of B literature.All the included literatures did not mention the allocation of hidden.Only eight studies illustrate the use of randomized methods,and other references only refer to "random".All included in the study only two mentioned the use of blindness,a single blind,a double blind.Most of the other literature did not mention the use of blindness.None of the six studies had fallen off / withdrawn and the rest did not mention it.Of which 10 are more stringent international diagnostic criteria,the remaining 63 for the domestic standard.Only 22 cases reported adverse reactions in the literature,29 articles describing the inclusion criteria and exclusion criteria,and the remaining articles did not provide relevant information.Included in the study containing moderate bias may be?According to the statistical results of Revman5.3 software merger,the effective rate and effective rate of the two groups were compared with the control group: P = 0.37,I= 8%(no significant heterogeneity),OR = 4.41,95(OR = 2.66,95% CI(2.03,3.49)),and the confidence interval of the group was(3.17,6.14),the rhombus fell on the right side of the vertical line;P = 0.07,I2= 39%(moderate heterogeneity)The difference between the two groups was statistically significant,indicating that Fried Glycyrrhizae Decoction and its addition and subtraction group treatment of arrhythmia clinical symptoms effective rate was significantly higher than the control group.Effective and effective rate of electrocardiogram improvement.(P = 0.42,I2= 3%),P =0.56,I2= 0%(no heterogeneity),OR(FM)= 2.9,95% confidence interval is(2.33,3.63);P = 0.42,I2= 3%(CI)is(1.68,2.43),and the rhombus falls on the right side of the vertical line,and the difference between the two is statistically significant(OR = 2.02(FM)),the 95% confidence interval(CI)significance.(ECG)in the treatment of arrhythmia was significantly higher than that of the control group(P<0.05).After the treatment of Holter ECG abnormal heart beat the number of times: P =0.00001 <0.1,I2= 97%(with severe heterogeneity).The mean difference MD =-251.80,95% confidence interval(CI)=(-329.82,-173.78),the diamond is located on the left side of the vertical line,the difference was statistically significant.The results showed that Holter's electrocardiogram(DCG)abnormalities in Fried Glycyrrhizae Decoction and its addition and subtraction group were less than that of western medicine and other routine treatmentP = 1,I2= 0%(no heterogeneity)OR = 4(FM),95% CI(3.47,4.62);P = 1,I2 = 0%(no heterogeneity)0.31,I2= 7%(heterogeneity),OR(FM)= 2.30,95% confidence interval(CI)was(2.06,2.56).The diamonds in the forest map fall on the right side of the vertical line,and the differences between the two groups are statistically significant.The effective rate of the total curative effect of Fried Glycyrrhizae Decoction and its addition and subtraction group was significantly better than that of western medicine and routine treatment and other proprietary Chinese medicines.The effective rate was also better than that of the control group.Adverse reaction occurred: P = 0.25,I2= 18%(low heterogeneity),OR(FM)= 0.25,95% confidence interval(0.17,0.44).Diamond is located on the left side of the invalid line,yo statistical difference.It can be considered that the incidence of arrhythmia treatment of Fried Glycyrrhizae Decoction and its addition and subtraction group with Fried Glycyrrhizae Decoction as the main intervention is lower than that of conventional treatment and western medicine treatment.Conclusions:(1)The efficacy of ECG,Holter electrocardiogram and clinical efficacy were higher than those of the control group.The incidence of adverse reactions was lower than that of western medicine,other proprietary Chinese medicine and routine treatment group.Which can be obtained Fried Glycyrrhizae Decoction and its addition and subtraction has a good effect and lower toxic side effects.(2)However,the quality of all the included clinical trials is not very high,there is a moderate bias may need to further develop a multi-center,large sample of high-quality randomized controlled trials for clinical decision-making to bring more reliable evidence.