The Protective Effect Of Montelukast Sodium On CBV3 Infection In Mice Myocardium

To investigate the cysteinyl aminoacyl receptor antagonist agent montelukast sodium(montelukast)for coxsackievirus B3(CVB3)infection the protective effe ct of myocardial injury in mice model.Methods:65 SPF BALB/c mice,male,weight is 16 to 20 gram were randomly di vided into four groups:group a blank control group(10 rats);group B virus co ntrol group(15 rats);group C for montelukast sodium group of small dose(20rats),group D for montelukast sodium group of large dose(20 rats).The inocul ation of the virus on the 14th day were all surviving mice,take heart,difference s in each group of mice the myocardial lesion score,nuclear factor kB(NF-?B)was observed through various detection technologies.Results:Montelukast sodium treatment group myocardial NF-?B mRNA and protei n expression levels were lower than that of the virus control group(P<0.05),and high dose group significantly;at the same time of montelukast sodium in tr eatment group and virus control group myocardial NF-?B mRNA and protein ex pression level and the myocardial lesion score was positively correlated(r = 0.77,P<0.05).Conclusion:Montelukast sodium on myocardial injury in mice serum nuclear factor ?B(NF-?B)inhibition,especially significant effect of high dose group and montel ukast sodium on CVB3 infection of myocardium in mice has a protective effec..