The Relationship Between The Expression Of AGGF1,HIF-1? And VEGF In Esophageal Squamous Cell Carcinoma And The Prognosis Of Radiotherapy

Objective:Esophageal cancer is a common upper gastrointestinal malignant tum or and radiotherapy is one of the main treatment of esophageal cancer.Our study is to investigate the expressions of AGGF1?HIF-1? and VEGF in esophageal squamous cell carcinoma(ESCC)and their relationships with clinicopathological features?curative effect of radiotherapy and prognosis of ESCC.Methods:The expressions of AGGF1?HIF-1? and VEGF in 79 cases of ESCC and 20 cases of normal esop hageal tissue were examined using SP immunohistochemical staining and were analyzed according to the clinicopathological features and follow-up data.Result:The expressions of AGGF1(?2=18.975,P<0.001)?HIF-1?(?2=26.884,P<0.001)an d VEGF(?2=22.702,P<0.001)In 79 cases of ESCC were significantly higher than those in 20 cases of normal esophageal tissue.The expressions of AGGF1(?2=8.134,P=0.004)and VEGF(?2=5.175,P=0.023)in ESCC were significantly related to the lymphnode metastasis;The expression of HIF-1? was significantly related to the clinical stage(?2=5.882,P=0.015)?lymph node metastasis(?2=7.712,P=0.005)and the depth of invasion(?2=5.538,P=0.019).The expression of VEGF in ESCC was significantly positively related to the expression of HIF-1?(r=0.333,P=0.003);The expression of AGGF1 was significantly positively related to the expressi on of VEGF(r=0.790,P<0.001).The radiotherapy curative effect was significantly negatively related to the expression of HIF-1?(r=-0.246,P=0.029).The OS of the p ositive teams of AGGF1(P=0.170)and VEGF(P=0.229)was shorter than the nega tive teams;The OS of the positive team of HIF-1? was shorter than the negative team significantly(P=0,013).Cox-proportional multivariate analysis showed that positive expression of HIF-1?(P=0.002)?depth of invasion(P=0.005)and clinical stage(P<0.001)were significant prognostic factor in overall survival.Conclusion:AGGF1?HIF-1? and VEGF have high expressions in ESCC,and they are closely related to the clinicopathological features of ESCC.The over expression of them may have influence on the curative effect of radiotherapy and the survival prognosis of ESCC,which can offer new ideals and methods for the treatment of ESCC.