Study On The Difference Of Inflammatory Markers In Patients With Bacterial Infection At Different Bacteria Strain

Objective:To investigate the difference of PCT(procalcitonin)and other inflammatory markers in different parts of different strains of bacterial infection.Methods: A retrospective analysis of 324 patients with bacterial infection from January 2015 to December 2015 was made;According to the results of bacterial detection,the strains were divided into gram negative(G-)bacteria group and gram positive(G+)bacteria group;and according to the different parts,divided into three groups: lung,urinary tract,blood flow,and each group was divided into G-bacterial group and G+ bacterial group.Analyze the results.The ROC curve was used to analyze the ability of PCT and IL-6 to identify Gbacteria in bloodstream infection.Results:(1)324 cases of bacterial infection,G-infection in 194 cases,accounting for 59.9%,G+ infection in 130 cases,accounting for 40.1%.In gram negative bacteria in Bauman Acinetobacter,Escherichia coli and Klebsiella pneumoniae resistant bacteria in the majority;G+ methoxy sensitive Staphylococcus aureus in 29 cases,methicillin-resistant Staphylococcus aureus in 13 cases,coagulase negative Staphylococcus aureus in 15 cases,34 cases of Enterococcus faecium,Enterococcus faecalis in 13 cases.1 cases of raffinose enterococcus;(2)There was no significant difference between G+ group and G-group;(3)There was no significant difference between the G+ group and the G-group in patients with pulmonary infection;(4)There was no significant difference between the G+ group and the G-group of patients with urinary tract infection;(5)The PCT level of G-group was higher than that of G+ group(t =2.355,P<0.05),and the IL-6 level of G-group was higher than that of G+ group(t =2.588,P<0.05),and the difference was statistically significant.PCT at 0.73 ng/ml(AUC:0.733,P:0.001,95%CI:0.601 ~ 0.865),the sensitivity of predicting G-bacterial infection was 82.8%,the specificity was 71.4%.Conclusions:The levels of PCT and IL-6 were higher than those of gram positive bacteria in bloodstream infection with Gram negative bacteria infection,and there was no difference between G-bacteria and G+ bacteria in patients with simple pulmonary infection or urinary tract infection.PCT can be used to identify G-bacteria and G+ bacteria.They can be used as a reference for the early application of antibiotics.