Relationships Between Serum Thyroid Stimulating Hormone And Papillary Thyroid Microcarcinoma

Objective: To discuss the relationships between thyroid stimulating hormone(TSH)and clinicopathologic features of the papillary thyroid microcarcinoma(PTMC)patients.Methods: The relevant clinicopathologic data of Patients with thyroid lesions were analyzed retrospectively from January 2012 to April 2015 in our hospital.Including: TSH levels,gender,age,etc.Among them 806 cases Meet the criteria.postoperative pathological examination confirmed the diagnosis of PTMC in 403 cases,and 403 cases of benign thyroid nodules(BTN),the history data and clinicopathologic features of selected cases that meet the criterion of selection were retrospectively analyzed.TSH and anti thyroid globulin antibody(TGAb)levels and demographics(including:gender,age,ethnicity,tumor size,etc)between the 2 groups are analyzed;finally the prevalence of ratio of PTMC in different TSH levels were compared.Univariate and multivariate analysis were performed to determine the risk factors of PTMC.Results: In the total case,173 were male,633 were female,the sexual ratio: 1:4.30.in the PTMC group,76 were male,327 were female,sexual ratio: 1:4.30;in the benign group,97 were male,306 were female,the sexual ratio: 1:3.15.gender composition no statistical significance in two groups(χ~2=3.246,P=0.072).and age was statistically significant(Z=-5.855,P=0.001).The differences of preoperative TSH levels between the two groups was statistical significance(Z=-6.233,P=0.001),The constitution of ethnics of two groups was different(χ2=38.961,P=0.001).Logistic regression analysis display that age and TSH level were the independent risk factors of PTMC(age: OR=0.914,P=0.027;TSH: OR=4.662,P=0.008).Conclusion: The level of serum TSH in PTMC patients is higher than in patients with benign thyroid nodules.TSH level is probably predictive of malignancy of PTMC.