Association Of Aldosterone And Serum Surfactant Proteins In Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective: The present study was to investigate the association of aldosterone excess and pulmonary surfactant protein levels in the patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods: This is a cross-sectional study.Patients with OSAHS confirmed by polysomnography were enrolled,circulating levels of aldosterone(ALD)and surfactant proteins(SP-A,B,C and D)were measured and SPs were compared between higher and normal plasma aldosterone concentration(PAC).Association of key variables and PAC was then evaluated by univariate and multiple linear regression analysis.Results: A total of 86 patients with OSAS were enrolled.Compared with N-ALD group(PAC<15ng/dl),H-ALD group(PAC?15ng/dl)had lower serum SP-B level(40.10±5.76ng/L vs 43.16±6.89ng/L,p=0.038).Correlation analysis showed that PAC was negatively correlated with SP-B(r=-0.361,P=0.043)by controlling AHI.Multiple linear regression analysis showed that SP-B levels were positively associated with PAC,independent of AHI,MSaO2 and plasma potassium.Conclusion: In patients with OSAHS,PAC might repress synthesis of SP-B,presented as decreased serum SP-B,which needs further confirmation.