| Objective:Observe the clinical curative efficacy and safety of Zehesijun Tang on treating Nonalcoholic steatohepatitis(NASH)of spleen-deficiency and Phlegmatic-hygrosis,and provide certain theoretical basis for the treatment.Methods: 90 cases with Nonalcoholic steatohepatitis(NASH)of spleen-deficiency and Phlegmatic-hygrosis were divided into two groups at random,the treatment group and the control group,45 cases in each group.In the course of treatment,there were 2 drop-out and 3 exclusions in the treatment group,there were 4 drop-out and 5exclusions in the control group;consequently,there were 40 cases in the treatment group and 36 cases in the control group.The comparative differences in sex,age,course of disease and other aspects between patients in two groups was not statistically significant.The treatment group was given Zehesijun Tang.At the same time,the control group was given Polyene Phosphatidylcholine Capsules.The clinical efficacy was observed after treatment for three months for both groups.Results:1.We found that in the treatment group,10 cases recovered,20 cases significantly improved,7 cases effective and 3 cases ineffective.The total effective rate is 92.50%.In the control group,5 cases recovered,14 cases significantly improved,8 cases effective and 9 cases ineffective.The total effective rate is 75.00%.The treatment group is better than the control group in effective rate(P<0.05).2.After treatment,the TCM syndrome total scores of both groups of patients were significantly improved(P<0.01),comparing with prior treatment,and also the treatment group improved better than the control group in the aspects of the TCMsyndrome total scores(P<0.05).3.After treatment,the differences in improving distension under right ribs,lassitude,viscous feces,epigastric distension and depression had statistical significance in the treatment group by comparing with the control group(P<0.05);The differences in improving inappetency,dizziness and nausea had no significant statistical significance in the treatment group by comparing with the control group(P>0.05).4.There was no obvious adverse reaction found in the course of treatment for both groups of patients.Conclusion : It is effective and safe that using Zehesijun Tang to treat Nonalcoholic steatohepatitis(NASH)of spleen-deficiency and Phlegmatic-hygrosis. |
