| Background and Objective:Lung cancer is a malignant tumour of the highest morbidity and mortality in the world.According to reports,there are 733 thousand and 300 new lung cancer patients newly increased,and 610 thousand and 200 people death in 2015 in China.It is topped at the tumor list.Non-small cell lung cancer(NSCLC)accounts for about 85% of the primary lung cancer,and more than 70% patients with locally advanced or distant metastasis in the treatment.Targeted therapy plays a more and more important role in advanced non-small cell lung cancer.EGFR mutation is the most common gene mutation in patients with NSCLC.The treatment of EGFR is the most widely used and the most effective gene targeted therapy in NSCLC.Many international guidelines are recommended to detected the EGFR mutation before the treatment of advanced non-small cell lung cancer.EGFR mutation detection is widely used in many countries and become clinical routine test items,in order to ensure that patients receive the most appropriate treatment options.The purpose of this study was to analysis collect EGFR mutation detection status data of NSCLC in No.1 Hospital of Jilin University patients,including EGFR inspection proportion(detection rate),analyzed the related factors that influence the EGFR test,and the relationship between EGFR mutation detection and general clinical pathological features.The results of EGFR mutation detection were also statistically analyzed.Methods:We retrospectively analyzed the data of 353 patients with advanced non-small cell lung cancer(IIIB~IV)for the first time confirmed or recurrence admitted to No.1 Hospital of Jilin University during2014-1-1~2015-12-31.We useing the SPSS21.0 to analyzed the datas,using ?2test or Fisher's exact test to analyze each demographic and clinical characteristics of EGFR gene mutation.Results:1.In 353 patients,178 patients were collected from EGFR gene mutation detection,detection rate was 50.4%.In these patients,and EGFR mutation negative were 97 cases(54.5%).We found that the most common were 19 and21 exons,21-L858 R has the largest proportion(35/81;43.2%),next is19-del(32/81;39.5%).The most commonly used EGFR mutation detection method for ARMS.2.In this study,a total of 353 patients,the male group of 209 cases,the delivery of patients with a total of 84 cases,the detection rate was 40.2%%;female group of 144 cases,the delivery of patients in 94 cases,the detection rate was 65.3%%;smoking index < 400 group of 204 cases,the detection rate was 63.7%(130/204);smoking index?400 group of 149 cases,the detection rate was 32.2%(48/149).There were 249 cases of adenocarcinoma,the detection rate was about 66.3%(165/249),and the number of cases in non adenocarcinoma group were 104,the detection rate was 12.5%(13/104).Histological specimens were 266 cases,the delivery of patients in 135 cases,the detection rate was 50.8%.Exfoliated cells were 66 cases,the delivery of patients in 43 cases,the detection rate was 65.2%.There were 21 cases without adequate samples,the delivery of patients in 0 cases.Respectively,showing statistical significance(P < 0.05).3.178 cases were detected EGFR gene,smoking index<400 group of130 cases,65 cases(50%)have EGFR mutation,smoking index?400 group of48 cases,16 cases(33.3%)have EGFR mutation;165 cases were adenocarcinoma,79 cases(47.9%)have EGFR mutation;non adenocarcinoma group were 13 cases,2 cases(15.4%)have EGFR mutation;24 cases were in stage M0,4 cases(16.7%)have mutation,154 cases were in M1,77 cases(50%)have mutation,respectively,showing statistical significance(P < 0.05).Conclusions:1.EGFR gene mutation detection rate was 50.4%,EGFR positive rate was 45.5%.The detection of EGFR gene mutation was associated with pathological type,and no correlation with age,sex,smoking index,sample tapes,medical insurance type.2.EGFR gene mutations was common in patients who were smoking index< 400,adenocarcinoma,stage M1.3.EGFR gene mutation mainly occurred in 19 and 21 exons.The most commonly used EGFR mutation detection method for ARMS. |
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