The Expression Pattern Of CUL4B In Hepatocellular Carcinoma

Objective: To investigate the expression of transcription factor CUL4 B in liver cancer tissues,adjacent tissues and distant metastases,and its relationship with the clinical pathological factors of malignant potential of liver cancer.Methods:This study selected 34 cases of patients with primary hepatocellular carcinoma to establish clinical databases including age,sex,drinking history,HBV history,hepatic cirrhosis,AFP,tumor size,tumor number,liver cancer BCLC staging,distant metastasis,portal vein tumor thrombus(PVTT),recurrence and pathological differentiation.And postoperative follow-up was performed on the patient to determine the disease free survival(DFS)and overall survival(OS).Results:CUL4B was highly expressed in HCC tissues and distant metastasis,and was low or not expressed in normal liver tissues.CUL4 B protein in hepatocellular carcinoma tissues with high expression of HBs Ag(P=0.044),liver cirrhosis(P=0.006),AFP positive(P=0.020),tumor diameter >5cm(P=0.048),tumor number >1(P=0.006),the low degree of tumor differentiation(P=0.020),and tumor recurrence(P=0.006).And there was no significant correlation between the expression of CUL4 B protein and the clinicopathological characteristics in the adjacent tissues.Kaplan-Meier Single factor analysis showed that the high expression of CUL4 B protein in cancer tissues was significantly correlated with tumor free survival time(median: 16.0 vs 60.8 months,P=0.019)and overall survival(median: 17.0 vs 90.9 months,P=0.001).Condusion : High expression of CUL4 B in hepatocellular carcinoma is closely related with many clinical pathological factors(poor differentiation,cirrhosis,tumor)and prognosis,and it is an independent risk factor for predicting postoperative recurrence and death.The high expression of CUL4 B protein may be a potential biological marker and therapeutic target in hepatocellular carcinoma patients.