| Objection:In this study we investigated the clinical curative effect of clearing he-at and removing dampness Tongluo for acute gouty arthritis,including remission rate,r-ecurrence rate and safety,and to observe the recurrence and evaluate its feasibility in clinical use,and explained from the pathogenesis of gout.Methods:We collected rheumatism patients from March 2016 to December 2016 i-n the hospital’s outpatient department and Department of Nanjing Hospital of Chinese Medicine.60 patients were randomly divided into two groups,treatment group 30 case-s,male 27 cases,female 3 cases;age were 21-67 years old,average were about 50.2 ± 13.1 years;acute exacerbated in 1-3 days,course of the disease were adout 1.7 ±0.8 years.The control group had 30 cases,28 male cases,2 female cases;age were in the range of 24 to 70 years old,average were adout 52.3 ±12.8 years old;acute at-tacked in 1-4 days,course of gout disease were within the range of 1.5 ±0.8 years.After the foundation treatment,the treatment group:were given A,celecoxib(Pfizer,phar-maceuticals,Zhunzi J20120063)200mg,two times a day;B,given traditional Chinese medicine one dose a day,pre-scription:Atractylodes 10g,Phellodendron 10g,Cyathula 10g,coix seed 30g,dioscorea sativa 30g,corn 10g,Alisma 10g,Poria 30g 10g,Ligu-sticum walich l0g.The course of treatment were 10 days.Control group:celecoxib(Pfizer pharmaceuticals J20120063)200mg,two times a day,for 10 days.After the cou-rse of treatment,the change of clinical symptoms and the level of serum uric acid be-fore were recorded and after tre-atment to evaluate the therapeutic effect.Blood bioch-emical indexes were examined be-fore and after treatment to observe the safety.Results:1.Symptom score:There were no significant differences in the scores of sympto-m score between the two groups(P>0.05)before treatment.After the treatment of 10 days,the two groups of symptoms and signs were significantly decreased,and treat-ment group were significantly lower compared with the control group(P<0.05).2.There were no significant differences in serum uric acid(UA),erythrocyte sedim-entation rate(ESR)and C-reactive protein(CRP)between the two groups pre-treatment.The levels of serum UA,ESR and CRP were significantly reduced after treatment.The levels of serum UA,ESR and CRP were significantly lower than those in the control group(P<0.05).3.The total effective rate and clinical efficacy of the two groups were compared:af-ter the treatment,in the treatment group 11 cases were cured,17 cases were impro-ved,2 cases were invalidity,the total effective rate was 93.3%,in the control group 7 cases were cured,16 cases were improved,7 cases were invalidity,the total effectiv-e rate was 76.7%.The difference of the two groups were statistically significant(P<0.05).4.After follow-up of 3 months showed no significant in safety problems in treat-ment group and control group.Conclusion:The patients in the treatment group were superior to the control group in terms of symptoms,signs,laboratory observation,treatment efficiency.The combina-tion use of Chinese medicine,could decreased the side effects of celecoxib.In conclusi-on,t-he combined application of traditional Chinese with western medicine,improve t-herapeutic effect.The therapeutic schedule of combing traditional Chinese with western medicine is worthy of popularization and application in clinical. |
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