Analysis Of Influence Factors On Apparent Diffusion Coefficient Values In Patients With Chronic Hepatitis B

Purpose: To evaluate whether there were differences between apparent diffusion coefficient (ADC) values derived from 3.0 T and 1.5 T MR diffusion-weighted imaging(DWI) in liver for patients with Chronic Hepatitis B. Objects and Method: From January 2016 to November 2016, 20 healthy volunteers and 40 patients with Chronic Hepatitis B in total enrolled into this research were divided into three groups (control group, mild inflammation group, moderate to severe inflammation group).The 40 patients with Chronic Hepatitis B prospectively underwent both 1.5 T and 3.0 T DWI,T2WI,T1 dual sequences from the same vendor before liver biopsy,b values=0?600?800?1000 s/mm2 .The interval between two scans was within 15 minutes, the protocol was respiratory-triggered DWI(RT-DWI).The ADC values of two field strengths were measured using ROI method.Bland-Altman tests and paired t-tests were used to compare ADC values in liver for the patients with Chronic Hepatitis B obtained at 1.5 T and 3.0 T. Results: The ADC values of different b values for patients with mild inflammation at 1.5 T were ( 1.24±0.01 ?1.44±0.02) ×10-3mm2/s,The ADC values of different b values for patients with mild inflammation at 3.0 T were (1.20±0.01?1.39±0.02)× 10-3mm2/s,There were significantly differences between the ADC values derived from 3.0 T and 1.5 T (p<0.001); The ADC values of different b values for patients with moderate to severe inflammation at 1.5 T were(1.19±0.03 ? 1.33±0.03)×10-3mm2/s, The ADC values of different b values for patients with moderate to severe inflammation at 3.0 T were (1.14±0.02?1.26±0.03)×10-3mm2/s.There were significantly differences between the ADC values derived from 3.0 T and 1.5 T(p<0.001). Conclusions: Different field strengths had influence on ADC values in liver,the ADC values derived from 3.0 T in liver were lower than the ADC values derived from 1.5 T in liver.Purpose: To evaluate whether there were differences between apparent diffusion coefficient (ADC) values derived from 3.0 T diffusion-weighted imaging (DWI) in liver at different b values for patients with Chronic Hepatitis B. Objects and Method: From January 2016 to November 2016, 20 healthy volunteers and 40 patients with Chronic Hepatitis B in total enrolled into this research were divided into three groups (control group, mild inflammation group, moderate to severe inflammation group). The 40 patients with Chronic Hepatitis B prospectively underwent 3.0 T DWI sequence before liver biopsy,b values=0?600?800?1000 s/mm2 .The interval between two scans was within 15 minutes,the protocol was respiratory-triggered DWI(RT-DWI).The ADC values were measured using ROI method. Bland-Altman tests?paired t-tests and analysis of variance were used to compare ADC values in liver for the patients with Chronic Hepatitis B derived from 3.0T.Results: The ADC values of different b values for control group were (1.58±0.05)×10-3mm2/s?(1.50±0.05) ×10-3mm2/s?(1.25±0.02) ×10-3mm2/s; The ADC values of different b values for patients of mild inflammation group were (1.39 ± 0.02) × 10-3mm2/s?(1.31 ± 0.02) ×10-3mm2/s?( 1.20 ± 0.01) ×10-3mm2/s; The ADC values of different b values for patients of moderate to severe inflammation group were ( 1.26 ± 0.03)×10-3mm2/s?( 1.19 ± 0.02) ×10-3mm2/s?( 1.14 ±0.02) ×10-3mm2/s. As the increasing of b values, the ADC values of every group derived from 3.0T were reducing, and there were significantly differences between every two ADC values of different b values for the same subject (p<0.001), b values and ADC values in liver were negatively correlated (r=-0.887?-0.967,p<0.001). There were significantly differences between ADC values for patients of different degrees of liver inflammation for the same b value (p<0.001),degrees of liver inflammation and ADC values in liver were negatively correlated (r= -0.931-0.962,p<0.001 ) .Conclusions: Different b values had influence on the ADC values in liver for patients with Chronic Hepatitis B. There were significantly differences between ADC values in liver for the same subject. B values and ADC values of liver were negatively correlated, and the correlation is higher.