Clinical Analysis Of Hepatic Neuroendocrine Tumor

Objective:Liver is the common organ to metastasis for the gastrointestinal tract and the pancreas neuroendocrine tumors,but there are still very rare neuroendocrine cancer can origin from the liver.To elucidate the clinicopathologic features,grading,treatment protocols,and prognostic of neuroendocrine tumor with liver metastasis and primary hepatic neuroendocrine tumor,the data of 40 cases of hepatic neuroendocrine tumors which were hospitalized in our hospital during Jan 2012 and Jan 2017 were analyzed retrospectively.Methods:The data of 40 cases of hepatic neuroendocrine tumors which were hospitalized in our hospital during Jan 2012 and Jan 2017 were analyzed retrospectively.Firstly,we collect the general characteristics of registered patients:age,sex,smoking and drinking history,family history of cancer,past history and related checks,test(abdominal B ultrasound,CT scan,endoscopy,blood tests,etc.).Secondly,we collect the pathological and biological characteristics:routine HE staining and microscopic observation of tumor cell aggregation status,size,morphology and mitotic imaging.,the tumor location,tumor size and lymph node metastasis.Thirdly,the treatment of hepatic neuroendocrine tumors:including surgical methods,hepatic artery embolization,radiofrequency ablation and chemotherapy;Fourthly,follow-up survival of patients with prognosis.The statistical analysis was performed by SPSS software version 7.0 software.Results:The clinical manifestations of primary and metastatic hepatic neuroendocrine tumor were nonspecific and variable in the early stage,most of the diseases were found firstly by physical examination.The incidence of primary hepatic neuroendocrine tumor has no significance difference in gender while metastatic hepatic neuroendocrine tumors are often found in older men aged 50-59 years.Diagnosis of these two diseases was depended on immunohistochemically and the absence of extrahepatic primary tumor.Immunohistologically,synaptophysin,CD56 and chromogranin A should be used as diagnosis markers to precisely diagnose primary and metastatic hepatic neuroendocrine neoplasm.The outcome of them is mostly related to its resectability.Total resection of the tumor is most commonly suggested.Primary surgery integrated with chemotherapy,transarterial chemoembolization or radiotherapy is considered to be an effective modality for hepatic neuroendocrine tumor.Conclusions:Hepatic neuroendocrine tumor is a disease without specific clinical manifestation in the early stage.The diagnosis depends on the immunohistochemistry and whether there is extrahepatic primary tumor or not.Tumor grading and surgical resection could be significant factors of prognosis.Surgical resection is the most effective whether for primary HNET or metastatic HNET.