The Diagnostic Value Of Early Clinical Research Procalcitonin In Pulmonary Infections After Abdominal Surgery In Elderly

Purpose:Under normal circumstances,PCT is produced by the C cells of the thyroid gland,its half-life in the blood is 25~30h,and the stability is good and easy detection.In healthy human blood PCT cannot be measured(<0.1ng/ml),severe infection(such as bacteria,parasites and fungal infections)and systemic manifestations,PCT concentration can be doubled.Elderly patients with low immunity after abdominal surgery are prone to pulmonary infection.To investigate the clinical value of abdominal surgery in elderly lung infection procalcitonin diagnostic applications,and to provide a reference basis for early diagnosis.Methods:A total of 98 treatment of elderly patients with abdominal surgery from Oct.2012 to Oct.2015 were selected and divided into infection group(42 cases)and uninfected group(56 cases),while 30 cases of healthy people selected as controls group.The levels of procalcitonin,C-reactive protein and white blood cell count were determined and compared among the two groups on day 1,5,and 9 after the surgical treatments;the sensitivity and specificity of the three indicators in the diagnosis of infections were evaluation,and the statistical analysis was performed with the use of SPSS 19.0 software.Results:Serum PCT level limited increased in infection group [(6.74±3.58)ng/ml] after the surgical treatments,and recovered after infection controlled [(0.38 ±0.34)ng/ml].The uninfected group serum PCT level transient increased from [(0.12±0.28)ng/ml] before operation to [(1.65±0.37)ng/ml] after operation and fell down to [(0.19 ± 0.13)ng/ml] at 9th day after operation.A statistically significant was observed between two groups(P<0.01).On day 1 after the surgeries,the levels of PCT,CRP,and WBC of the infection group and the non-infection group were significantly higher than those of the control group(P<0.01),however,there was no significant difference in the level of PCT,CRP or WBC between the infection group and the non-infection group.On day 5 and 9 after the surgeries,the levels of PCT of the infection group were significantly higher than those of the non-infection group(t=2.735?2.543,P<0.01),the levels of CRP of the infection group were significantly higher than those of the non-infection group(t=2.013,P<0.05?t=3.274,P<0.01).On day 5 after the surgeries,the levels of WBC of the infection group were significantly higher than those of the non-infection group(t=2.165,P<0.05),On day 9 after the surgeries,the levels of WBC of the infection group were not significantly higher than those of the non-infection group(t=1.175,P>0.05).The sensitivity and specificity of the PCT in diagnosis of the postoperative infections were respectively86.9% and 89.1%,significantly higher those of the CRP and WBC.Conclusions:PCT as after abdominal surgery in elderly lung infection early diagnostic criteria,and both the sensitivity and specificity of the PCT are higher than those of the CRP and WBC in diagnosis of the postoperative lung infection in the elderly patients.