Relevant Research Between White Matter Alterations And Cognitive Function Damage In Young And Middle-Aged End-Stage Renal Disease Patients With Peritoneal Dialysis

Objective To investigate the association between cognitive deficits and microstructural white matter(WM)alterations with tract-based spatial statistics(TBSS)of diffusion tensor imaging(DTI)data in young and middle-aged maintenance peritoneal dialysis end-stage renal disease(ESRD)patients.Methods 21 maintenance peritoneum dialysis ESRD patients with no visible lesion on MRI and 20 healthy controls underwent diffusion tensor imaging(DTI)and Mini Mental State Examination(MMSE).Tract-based spatial statistics(TBSS)analyses was performed to evaluate WM changes in the patients,include anisotropy(FA),mean diffusivity radial diffusivity(RD),value and axial diffusivity(AD)values.Relationships between MMSE scores and the DTI index were tested by correlation analysis at the voxel level.Results In patients with ESRD,the FA value was significantly decreased in the left anterior thalamic radiations,bilateral superior longitudinal fasciculus,bilateral fronto-occipital fasciculus,Left forceps minor,corpus callosum,left corticospinal tract,right anterior longitudinal fasciculus,pons,whereas AD,RD and MD values were significantly increased(P<0.05,corrected by TFEC).Mild decrements in cognition was found,mainly included attention,language and visua-spatial ability.There was no significant correlation between each DTI indices and MMSE scores.Conclusion The microstructure changed significantly,like WM integrity reduction and demyelination,and mild decrements was found in cognition was found in young and middle-aged maintenance peritoneal dialysis ESRD patients,although there was no visible lesion on MRI.