Pharmaceutical Research Of Hospital Preparations On Anaphylactic Rhinitis Cataplasm

The prescription of Anaphylactic Rhinitis is a representative clinical effective prescription of the otolaryngology of Hubei Province TCM hospital,which consists of Sinapis semen,Scutellariae radix,Xanthii fructus and other seven kinds of traditional Chinese medicine.It has the function of dredge the channel,Anti-inflammation and relieve itching,which has the obvious curative effect on Paroxysmal sneezing,Swollen nasal membranes,Rhinocnesmus and Rhinocnesmus.In order to make it better use of the clinical effect of modified Anaphylactic Rhinitis Cataplasm.This research is basied on the foundation of the clinical curative effect,the proposed in accordance with the State Food and Drug Administration “medical establishment preparation registered management approach(Trial)”(Decree NO.20 of the Bureau)requirements,to carry out the preparation process,quality standard and stability studies on particle system of the Anaphylactic Rhinitis Cataplasm,the development to lay the foundation for the hospital preparation.By adopting the combination of modern and traditional preparation technology,the extraction and preparation for this new type hospital preparation has carried on a systematic research.First,the single factor investigation has sorted out the best extraction of the volatile oil of Sinapis semen,Xanthii fructus and other 4 kinds of traditional Chinese medicine.The orthogonal experiment has established the best water decoction extraction process,obtained reliable technical parameters.This systematic research for forming process of Anaphylactic Rhinitis Cataplasm is based on the choice of the auxiliary material;technical parameter;the proportion of auxiliary material,achieved a reliable preparation technics.In addition,the enlarge test can provide a reference for the transition toindustrialization production.By using the modern analysis method of Anaphylactic Rhinitis Cataplasm,thin layer identification of the characteristics of particles,a variety of effective component content determination,the paste content,compactibility,viscidity and the detection of microbial limit,it has established pefect quality criterion for this dosage form,which can effectively control the inner quality.The thin layer identification in quality standard research,under the Scutellaria baicalensis,Astragalus membranaceus,Biond Magnolia Flower and Saposhnikovia divaricata has carried on the qualitative identification;The study on determination of content of baicalin in Scutellaria baicalensis can represente the quality of this dosage.According to the 2015 editon of “Chinese pharmacopoeia”in the fourth general principles of the “guidelines”for raw matear medicine and preparation stability test requirements,on the basis of the established quality standard draft for the Anaphylactic Rhinitis Cataplasm,The investigation results of accelerated stability test and the room temperature sample preliminary stability test show that the various examining indexs have no obvious change within the inspection period of stable quality.It also provides a experimental basis for the validity of clinical application.